Toxins
MilliporeSigma Pertussis Toxin, Bordetella pertussis, 50ug
Pertussis Toxin, Bordetella pertussis, catalyzes ADP-ribosylation of guanine nucleotide-binding regulatory proteins Gi, Go, and Gt. 70323-44-3, 50ug
Selleck Chemical LLC Lycorine-25mg
Lycorine (Galanthidine, Amarylline, Narcissine, Licorine, Belamarine) is a toxic crystalline alkaloid found in various Amaryllidaceae species that weakly inhibits acetylcholinesterase (AChE) and ascorbic acid biosynthesis.
Selleck Chemical LLC Cucurbitacin I-1mg
Cucurbitacin-I (Elatericin B, JSI 124, NSC 521777), a natural cell-permeable triterpenoid isolated from Cucurbitaceae, is a novel selective inhibitor of JAK2/STAT3.
Apexbio Technology LLC MATRINE 100MG
Matrine (CAS 519-02-8) is an alkaloid derived from plants in the Sophora genus with demonstrated anticancer and anti-inflammatory activities It functions in part through agonism of kappa-opioid and possibly other receptors Matrine inhibits the MNK45 gastric cancer cell line proliferation (IC50 540 g/ml MTT assay) by modifying protein expression profiles (e g NF- B XIAP CIAP p-ERK) In vitro matrine induces apoptosis in NSCLC cells through ROS generation caspase activation and p38 pathway modulation Animal studies suggest therapeutic roles in cardiac injury and sepsis-related lung inflammation
Cayman Chemical DIphthRIa ToxIn CRM197 mutn
A monoclonal antibody-derived tetrapeptide that acts as a partial agonist at the glycine site of the NMDA receptor active in vivo and readily passes the BBB blocks neuropathic pain enhances learning and memory and significantly reduces anxiety in animals
Cayman Chemical 16-epI LatrunculIn B 100ug
A potent selective and cell-permeable inhibitor of the BRPF1 bromodomain (IC50 80 nM) disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3 3
Cayman Chemical VIrIdItoxIn 500ug
A KLF5 inhibitor (IC50 2.3 M) decreases KLF5 expression in and reduces growth of DLD-1 colorectal adenocarcinoma cells in a concentration-dependent manner selectively inhibits proliferation of cancer cell lines that highly express KLF5 in the NCI-60 panel of cancer cell lines
Cayman Chemical GABAA RECPTR a2 SubunIt Pol
An antispasmodic agent suppresses contractions induced by potassium or ACh in isolated guinea pig detrusor smooth muscle blocks spontaneous and vagal-stimulated colonic motility in rabbits reduces the number of abdominal contractions induced by 5-HTP or high volume rectal distension in rats at 75 g/animal
Cayman Chemical GABAA RECPTR 3 SubunIt Pol
A diacylglycerol contains stearic acid at the sn-1 position and lauric acid at the sn-2 position a substrate for the rat diacylglycerol lipase DDHD2
Cayman Chemical WRnr Syndrome RecQ HelIcase
A biotinylated derivative of sphingosine (d181) has been used in assays to detect the phosphorylation activity of SPHK1 and SPHK2 in cell lysates
Cayman Chemical Werner Syndrome RecQ Helicase
A building block has been used in the synthesis of compounds with cytokinin-like activity
Cayman Chemical Werner Syndrome RecQ Helicase
A building block has been used in the synthesis of compounds with cytokinin-like activity
Cayman Chemical Nav1 7 Blocker 52 5mg
A fluorescent cholesterol analog has been used in a variety of in vitro and in vivo applications including analysis of steroid uptake and esterification intracellular localization and targeting and metabolism in mammalian and bacterial cells and intestinal absorption of cholesterol in hamsters ex/em 472/540 nm respectively when incorporated DMPC vesicles emission maximum is solvent-dependent and increases as solvent polarity increases