General Cell Based Assays
Eurofins Discoverx PathHunter Human MTNR1B β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human MTNR1B β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure MTNR1B (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human GPR39 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human GPR39 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure GPR39 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress GLP1R Total GPCR Internalization Assay, 2-Plate Kit. (93-1075E3CP5M)
The PathHunter GLP1R Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of GLP1R via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged GLP1R and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the GLP1R receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Medchemexpress LLC GNE-987 GSH linker-1 | 2417370-39-7 | C62H77F2N9O12S4 | 10MG
GNE-987 GSH linker-1 is a PROTAC-linker conjugate that pairs a BET-degrading warhead with a disulfide-containing glutathione-cleavable linker for use in PROTAC-antibody conjugate (PAC) research. It is intended as a research reagent for chemical biology studies involving targeted protein degradation and intracellular payload release.
- Enables targeted protein degradation when conjugated to antibodies.
- Contains a disulfide-based glutathione-cleavable linker for intracellular release.
- High chemical purity suitable for analytical and biological testing.
- Compatible with common solvents and recommended storage protocols.
- Applicable to studies of protein degradation pathways and PAC development.
Bioassay Systems EnzyFluo™ NADP/NADPH Assay Kit. For quantitative determination of NADP and NADPH and evaluation of drug effects on their metabolism (This product is a replacement for the discontinued product EFNP-100).
For quantitative determination of NADP and NADPH and evaluation of drug effects on their metabolism (This product is a replacement for the discontinued product EFNP-100). Key Features: Sensitive and accurate. Detection limit of 0.01 µM and linearity up to 1 µM NADP+/NADPH in 96-well plate assay. Convenient. The procedure involves adding a single working reagent, and reading the fluorescence at time zero and 30 min. Room temperature assay. High-throughput. Can be readily automated as a high-throughput 96-well plate assay for thousands of samples per day. Method: FL530/585nm. Samples: Cell, tissue extracts etc. Species: All. Procedure: Assay takes 30 min. Kit size: 100 tests. Detection limit: 0.01 µM.
Eurofins Discoverx PathHunter eXpress AVPR1B Activated GPCR Internalization Assay, 10pl Kit. (93-0722E3CP5L)
The PathHunter AVPR1B Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of AVPR1B via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged AVPR1B. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting AVPR1B-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress OPRL1 CHO-K1 GPCR Assay, 2-Plate Kit. (95-0115E2CP2M)
The cAMP Hunter OPRL1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. orphanin FQ) based activation of OPRL1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type OPRL1, a naturally Gi/Go coupled GPCR. Upon activation of OPRL1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress OPRM1 U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0213E3CP0L)
The PathHunter OPRM1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. met 5-enkephalin) based activation of OPRM1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged OPRM1 and EA-tagged β-Arrestin-2. Activation of OPRM1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress INSRb Functional Assay, 10-Plate Kit. (93-0466E3CP16L)
The PathHunter eXpress INSRb Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated INSRb dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged INSRb and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc AlphaScreen Mouse IgG Detection Kit, 50,000 Assay Points
AlphaScreen Mouse IgG Detection Kit, 50,000 Assay Points
Eurofins Discoverx PathHunter Human OXER1 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human OXER1 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure OXER1 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx cAMP Hunter™ Human RXFP4 Gi Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Human RXFP4 Gi Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure RXFP4 (GPCR) activity via decreased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human TORC3 (CRTC3) Nuclear Translocation Cell-Based Assay Kit (U2OS)
The PathHunter Human TORC3 (CRTC3) Stable Cell Line Nuclear Translocation Assay (U2OS) contains a stable clonal cell line used to measure CRTC/CREB pathway activation via nuclear translocation of TORC3. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human Apelin (APJ Receptor) Activated GPCR Internalization Cell-Based Assay Kit (U2OS)
The PathHunter Human Apelin (APJ Receptor) Stable Cell Line Activated GPCR Internalization Assay (U2OS) contains a stable clonal cell line used to measure AGTRL1 (GPCR) internalization via early-endosome localization. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.