General Cell Based Assays
Eurofins Discoverx PathHunter eXpress mCXCR6 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0512E2MCP0L)
The PathHunter mCXCR6 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CXCL16) based activation of mCXCR6 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCXCR6 and EA-tagged β-Arrestin-2. Activation of mCXCR6 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Echelon Biosciences Research Labs PI(4)P DiC4 500 ug
Phosphatidylinositol 4-phosphate diC4 (PI(4)P diC4) is a synthetic, purified dibutanoyl PI(4)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex. This item is non returnable
![MOLTOX Molecular Toxicology Inc STDisc TA102 [hisG428,rfa,pKM101,pAQ1], Consists of lyophilized & stablilized S.Typhimurium strain TA97a cells, For use as culture inoculum, 10 discs/vial, Store in Refrigerator](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00051761-DISCS.PNG-250.jpg)
MOLTOX Molecular Toxicology Inc STDisc TA102 [hisG428,rfa,pKM101,pAQ1], Consists of lyophilized & stablilized S.Typhimurium strain TA97a cells, For use as culture inoculum, 10 discs/vial, Store in Refrigerator
STDisc™ Salmonella typhimurium strains for use in the bacterial mutagenesis assay described by Maron & Ames, Mutat. Res. 113: 173, 1983. Most commonly employed bacterial strains for use in mutagenicity testing are provided in convenient lyophilized disc format. Strains are periodically characterized and verified for diagnostic performance. Confirmed strains are lyophilized in modified ATCC Reagent 18. After preservation, samples are cultured and their phenotypes and responses to diagnostic mutagens are determined. Strains are accompanied by Quality Control statements that include the results of phenotype confirmation tests, diagnostic mutagen response and viability assessment. Culture instructions are included with the QC Statement. The bacterial strains contained in STDiscs™ and ECDiscs™ are potential etiologic agents and are intended for use only by those skilled in the safe handling of potentially infectious agents.
Eurofins Discoverx PathHunter eXpress GCGR Total Internalization Assay, 2pl Kit. (93-0820E1CP0M)
The PathHunter GCGR Total Internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of GCGR via detection of localization to the early endosome. The included cell line overexpresses EA-tagged GCGR and a ProLink-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the GCGR receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Abcam Plasma Kallikrein Assay Kit
Plasma Kallikrein Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx AssayComplete Cell Plating 27 Reagent, 100. (93-0563R27A)
AssayComplete Cell Plating 27 Reagent is an optimized cell plating reagent for use in plating of Eurofins DiscoverX cell lines for assays. This reagent was optimized for maximal cell health and ligand responsiveness during assays while eliminating hormones and growth components which may lead to increased basal activity. This product is provided as a bottle of 100 mL. Please refer to cell line specific datasheet to determine the recommended cell plating reagent. For detailed product information, User manual and datasheet, visit www.discoverx.com/reagents.
Eurofins Discoverx PathHunter eXpress GRPR U2OS β-Arrestin GPCR Assay, 2-Plate Kit. (93-0229E3CP5M)
The PathHunter GRPR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. gastrin-releasing peptide) based activation of GRPR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GRPR and EA-tagged β-Arrestin-2. Activation of GRPR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GALR1 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0228E2CP0M)
The PathHunter GALR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. galanin) based activation of GALR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GALR1 and EA-tagged β-Arrestin-2. Activation of GALR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx AssayComplete Cell Plating 24 Reagent, 100. (93-0563R24A)
AssayComplete Cell Plating 24 Reagent is an optimized cell plating reagent for use in plating of Eurofins DiscoverX cell lines for assays. This reagent was optimized for maximal cell health and ligand responsiveness during assays while eliminating hormones and growth components which may lead to increased basal activity. This product is provided as a bottle of 100 mL. Please refer to cell line specific datasheet to determine the recommended cell plating reagent. For detailed product information, User manual and datasheet, visit www.discoverx.com/reagents.
Meso Scale Discovery R-PLEX Human GAS-6/AXL-L ASY
The R-PLEX Human Gas6/Axl-L Assay Kit from Meso Scale Discovery is a multiplex immunoassay for measuring human Gas6 and Axl proteins in serum plasma and cell culture supernatants It uses electrochemiluminescence detection for high sensitivity and broad dynamic range with low sample volume The kit includes a 96-well plate with capture antibodies detection antibodies calibrators and necessary reagents It quantifies Gas6 and Axl crucial for cell survival proliferation migration and phagocytosis in 3 5 hours performing 39 tests in duplicate
Sigma Aldrich Fine Chemicals Biosciences Phosphate Assay Kit suffic
Phosphate is one of the most abundant minerals in the human body and contains about 1 % of total body weight. Phosphate homeostasis is maintained by the several regulators such as parathyroid hormone (PTH) calcitriol and phosphatonins. Maintenance of phosphate homeostasis is essential for various biological processes such as energy metabolism cell signaling regulation of protein synthesis skeletal development and bone integrity. An adequate level of phosphate is needed for the process of apoptosis of mature chondrocytes in the growth plate. Phosphate deficiency is associated with the bone pathology and clinical illness.
Medchemexpress LLC cGAS Human His-SUM 100ug
Recombinant human cGAS (fragment G161-F522) expressed in E. coli with N-terminal 6xHis and SUMO tags. Supplied lyophilized with >90% purity and formulated in Tris-HCl or PBS with trehalose, this protein is suitable for biochemical and binding studies of cytosolic DNA sensing and cGAMP synthesis. Store lyophilized at -20°C; after reconstitution it is stable at 4°C for one week or at -20°C for extended storage when aliquoted.
Eurofins Discoverx PathHunter eXpress ADRA1B CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0274E2CP0M)
The PathHunter ADRA1B eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. epinephrine and norepinephrine) based activation of ADRA1B GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged ADRA1B and EA-tagged β-Arrestin-2. Activation of ADRA1B stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CALCR-RAMP2 (AMY2) CHO-K1 β-Arrestin GPCR Assay, 10pl Kit. (93-0267E2CP0L)
The PathHunter CALCR-RAMP2 (AMY2) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. calcitonin) based activation of CALCR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CALCR and EA-tagged β-Arrestin-2, along with untagged modulating protein RAMP2. Activation of CALCR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery U-PLEX Human A2M ASY
The Meso Scale Discovery U-PLEX Human A2M Assay is a multiplex immunoassay kit that enables simultaneous quantitative measurement of Alpha-2-Macroglobulin (A2M) in human serum plasma and cell culture supernatant samples This electrochemiluminescent assay utilizes MSD s proprietary SECTOR Imager and provides high sensitivity a broad dynamic range and requires low sample volume The kit includes a 96-well plate pre-coated with capture antibodies detection antibodies and calibrators and controls needed to generate a standard curve and validate assay performance This assay allows rapid reproducible quantification of A2M which plays a key role in regulating protease activity