General Cell Based Assays
Enzo Life Sciences Matrix Metalloproteinase-12 (MMP-12) fluorometric drug discovery kit (1x96wells)
A QUANTIZYME Assay System. The MMP-12 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-12 (MMP-12, metalloelastase, macrophage elastase) using a quenched fluorogenic peptide: OMNIMMP fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties. The assays are performed in a convenient 96-well microplate format. The kit is useful to screen inhibitors of MMP-12, a potential therapeutic target. Included are active enzyme, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet. Alternative name: Metalloelastase, Macrophage elastase. Applications: Fluorescent detection, HTS Activity assay.
Eurofins Discoverx PathHunter Human CMKLR1 Activated GPCR Internalization Cell-Based Assay Kit (U2OS)
The PathHunter Human CMKLR1 Stable Cell Line Activated GPCR Internalization Assay (U2OS) contains a stable clonal cell line used to measure CMKLR1 (GPCR) internalization via early-endosome localization. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Cayman Chemical NBD-Fructose 500UG
A fluorescent derivative of fructose; has been used to monitor fructose uptake by the GLUT5 transporter in MCF-7, MDA-MB-435, and MDA-MB-231 human breast cancer cells; ex/em = 472/538 nm, respectively
Eurofins Discoverx PathHunter Human MR Nuclear Receptor Protein Interaction Cell-Based Assay Kit (CHO-K1)
The PathHunter Human MR Nuclear Receptor Stable Cell Line Protein Interaction Assay (CHO-K1) contains a stable clonal cell line used to measure MR nuclear hormone receptor activation via nuclear translocation. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Human ADRB2 (W158A) ENDO-EA Pharmacotrafficking Cell-Based Assay Kit (U2OS)
The PathHunter Human ADRB2 (W158A) ENDO-EA Pharmacotrafficking Stable Cell Line Assay (U2OS) contains a stable clonal cell line used to measure pharmacochaperone-based rescue of the mutant ADRB2's trafficking to early endosomes. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx cAMP Hunter™ Human CHRM2 Gi Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Human CHRM2 Gi Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure CHRM2 (GPCR) activity via decreased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Abcam Cathepsin D Activity Assay Kit (Fluorometric)
Cathepsin D Activity Assay Kit (Fluorometric)
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx cAMP Hunter™ Mouse TAAR1 Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Mouse TAAR1 Gs Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure mouse TAAR1 (GPCR) activity via increased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx cAMP Hunter eXpress FPRL1 CHO-K1 GPCR Assay, 2-Plate Kit. (95-0044E2CP2M)
The cAMP Hunter FPRL1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of FPRL1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type FPRL1, a naturally Gi/Go coupled GPCR. Upon activation of FPRL1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc HTRF mAb Anti-6His XL665-Conjugate, 5,000 Assay Points
HTRF mAb Anti-6His XL665-Conjugate, 5,000 Assay Points
Cayman Chemical Cyclohexnoyl-Coenzyme A 500ug
An acyl-CoA that contains a cyclohexane group; formed through conversion of CHC by a succinyl-CoA transferase, and degraded by a dehydrogenase; converted to hippuric acid in submitochondrial fractions isolated from guinea pig liver
Eurofins Discoverx cAMP Hunter eXpress CXCR3 CHO-K1 GPCR Assay, 10-Plate Kit. (95-0054E2CP2L)
The cAMP Hunter CXCR3 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CXCL11/I-TAC) based activation of CXCR3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CXCR3, a naturally Gi/Go coupled GPCR. Upon activation of CXCR3, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Genscript Corporation PLAU/uPA active formBiotin
Plasminogen activator urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers PLAU inhibition could suppress tumor growth Collectively PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC
Eurofins Discoverx PathHunter eXpress IL17RD/TNFR2 Dimerization Assay, 2pl Kit. (93-1068E3CP5M)
The PathHunter IL17RD/TNFR2 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. TNFα) induced dimerization of IL17RD/TNFR2 receptors. This product uses EFC technology. The cell line included overexpresses IL17RD target protein fused to PK alongside TNFR2 target protein fused to EA. Upon ligand-induced dimerization of IL17RD/TNFR2, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery R-PLEX Human IL-23R ASY
The Meso Scale Discovery R-PLEX Human IL-23R Assay is a multiplex immunoassay for measuring IL-23R in human serum plasma and cell culture supernatants It uses electrochemiluminescence detection on patterned arrays for high sensitivity and a wide dynamic range The kit includes a plate with capture antibodies detection antibodies labeled with an electrochemiluminescent compound and calibrator and control samples for standard curve generation and assay validation It quantifies IL-23R with high precision and reproducibility suitable for 96 tests on MSD platforms