General Cell Based Assays
Eurofins Discoverx PathHunter eXpress NTSR1 Activated GPCR Internalization Assay, 2pl Kit. (93-0671E3CP5M)
The PathHunter NTSR1 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of NTSR1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged NTSR1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting NTSR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CXCR7 Activated GPCR Internalization Assay, 10pl Kit. (93-0738E3CP27L)
The PathHunter CXCR7 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of CXCR7 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CXCR7. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CXCR7-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress ErbB4/ErbB4 Dimerization Assay, 10pl Kit. (93-0961E3CP5L)
The PathHunter ErbB4/ErbB4 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. neuregulin-1 Beta 2) induced dimerization of ErbB4/ErbB4 receptors. This product uses EFC technology. The cell line included overexpresses ErbB4 target protein fused to PK alongside ErbB4 target protein fused to EA. Upon ligand-induced dimerization of ErbB4/ErbB4, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress PTAFR CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0236E2CP0M)
The PathHunter PTAFR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. PAF) based activation of PTAFR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTAFR and EA-tagged β-Arrestin-2. Activation of PTAFR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress IL23R/IL12RB1 Dimerization Assay, 2pl Kit. (93-1007E3CP0M)
The PathHunter IL23R/IL12RB1 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-23) induced dimerization of IL23R/IL12RB1 receptors. This product uses EFC technology. The cell line included overexpresses IL23R target protein fused to PK alongside IL12RB1 target protein fused to EA. Upon ligand-induced dimerization of IL23R/IL12RB1, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Meso Scale Discovery R-PLEX Human IL-17RB ASY
The R-PLEX Human IL-17RB Assay Kit from Meso Scale Discovery is a multiplex immunoassay that enables the simultaneous measurement of IL-17RB in human serum plasma and cell culture supernatants This assay utilizes MSD s electrochemiluminescent detection technology and provides high sensitivity up to a 7-log dynamic range and requires low sample volume The kit includes a 96-well plate pre-coated with capture antibodies detection antibodies calibrators and controls for the quantitative analysis of IL-17RB This assay allows for efficient and reproducible quantification of IL-17RB levels
Eurofins Discoverx ADP Hunter Plus, 500 (50,000 dp, 384-well). (90-0083XL)
The ADP Hunter Plus kit is a detection kit for the measurement of ADP produced as a product of kinase activity. It is used to detect substrate-induced activity of purified or semi-purified kinases. ADP produced by the kinase reacts with intermediate factors to produce a fluorescent dye precursor, which generates signal when combined with peroxide and peroxidase. The kit uses an end-point read. This detection kit contains reagents for 125 plates (384-well). For detailed product information, visit www.discoverx.com/products-applications/biochemical-assays.
![Medchemexpress LLC 11-(2-fluoropyridin-4-yl)-4,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene | 2173361-80-1 | 99.9% | C15H9FN4 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000260229.png-250.jpg)
Medchemexpress LLC 11-(2-fluoropyridin-4-yl)-4,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaene | 2173361-80-1 | 99.9% | C15H9FN4 | 10MG
Tau tracer 2 is a small-molecule PET tracer developed for imaging aggregated tau protein in neurodegenerative disease research. It binds selectively to tau aggregates and is used in preclinical and diagnostic studies to assess regional tau pathology with PET imaging.
- High affinity for aggregated tau enabling sensitive PET imaging.
- Suitable for preclinical and diagnostic research applications.
- High chemical purity suitable for analytical and radiolabeling workflows.
- Supplied in small-mass packages for tracer synthesis and testing.
- Characterized by molecular formula C15H9FN4 and CAS 2173361-80-1.
- Datasheet available with analytical and handling information.
Eurofins Discoverx PathHunter eXpress mGIPR U2OS β-Arrestin GPCR Assay, 2-Plate Kit. (93-0846E3MCP5M)
The PathHunter mGIPR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. GIP) based activation of mGIPR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mGIPR and EA-tagged β-Arrestin-2. Activation of mGIPR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress MC3R Total Internalization Assay, 10pl Kit. (93-0837E3CP0L)
The PathHunter MC3R Total Internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of MC3R via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged MC3R and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the MC3R receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress IL4R/IL2RG Dimerization Assay, 10pl Kit. (93-0988E3CP5L)
The PathHunter IL4R/IL2RG Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-4) induced dimerization of IL4R/IL2RG receptors. This product uses EFC technology. The cell line included overexpresses IL4R target protein fused to PK alongside IL2RG target protein fused to EA. Upon ligand-induced dimerization of IL4R/IL2RG, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Microsolv Technology Corporation Base Plate, Translucent Polypropylene, Micro-Sample Management System, universal, re-usable. 12/CS.
Accommodates and holds one Micro-Sample Insert Rack in the U-2D System. Made of low weight polypropylene plastic, they comply with ANSI standards for 96 well plates. When used with Racks of Inserts, the unique molded bottoms allow each insert to be supported on the bottom. Use in a vortex mixer or water bath can be used with enhanced performance. Also most plate readers can be used. Bases are reusable and can be refrigerated.
Eurofins Discoverx PathHunter eXpress PTHR2 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0306E2CP0M)
The PathHunter PTHR2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. PTH) based activation of PTHR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTHR2 and EA-tagged β-Arrestin-2. Activation of PTHR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Innovative Research Inc Rat Act tPA Kit
Rat Active tPA ELISA Kit - This rat tPA activity assay is intended for the quantitative determination of active tissue plasminogen activator (tPA) in rat plasma and other biological fluids. For research use only. Strip well format. Reagents for up to 96 tests. Functionally active rat tPA will form a covalent complex with the biotinylated human PAI-1 which is bound to the avidin on the plate. Only free active tPA will react with the PAI-1 bound to the plate. After appropriate washing steps, polyclonal anti-tPA primary antibody binds to the captured tPA. Excess antibody is washed away and bound primary antibody is then reacted with the secondary antibody conjugated to horseradish peroxidase. Following an additional washing step, TMB substrate is used for color development at 450nm. The amount of color development is directly proportional to the concentration of active tPA in the sample.
Eurofins Discoverx PathHunter eXpress GPR149 CHO-K1 β-Arrestin Orphan GPCR Assay, 2-Plate Kit. (93-0420E2ACP1M)
The PathHunter GPR149 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR149 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR149 and EA-tagged β-Arrestin-2. Activation of GPR149 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.