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Trop-2 also known as epithelial glycoprotein-1 antigen (EGP-1) is a protein that in humans is encoded by the TACSTD2 gene Mutations of this gene result in gelatinous drop-like corneal dystrophy an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness
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Trop-2 also known as epithelial glycoprotein-1 antigen (EGP-1) is a protein that in humans is encoded by the TACSTD2 gene Mutations of this gene result in gelatinous drop-like corneal dystrophy an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness
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Nectin-2 is an adhesion molecule that has been reported to play a role in tumor growth metastasis and tumor angiogenesis Nectin-2 expression in ovarian cancer may support tumor cell adhesion leading to growth and lymph node metastasis Effect of VEGF on Nectin-2 expression as well as permeability was investigated in HUVEC
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ErbB2 also known as Neu and Her2 is a type I membrane glycoprotein belonging to the ErbB family of tyrosine kinase receptors It serves as a receptor for the epidermal growth factor (EGF) family of growth factors Upon activation ERBB2 triggers the MEMO1-RHOA-DIAPH1 signaling pathway leading to the phosphorylation and inhibition of GSK3B at the cell membrane
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Mesothelin also known as MSLN is a protein that in humans is encoded by the MSLN gene Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF) Although it has been proposed that mesothelin may be involved in cell adhesion its biological function is not known A knockout mouse line that lacks mesothelin reproduces and develops normally
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Mesothelin also known as MSLN is a protein that in humans is encoded by the MSLN gene Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF) Although it has been proposed that mesothelin may be involved in cell adhesion its biological function is not known A knockout mouse line that lacks mesothelin reproduces and develops normally
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Mesothelin also known as MSLN is a protein that in humans is encoded by the MSLN gene Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF) Although it has been proposed that mesothelin may be involved in cell adhesion its biological function is not known A knockout mouse line that lacks mesothelin reproduces and develops normally
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CD46 was discovered in 1986 during a search for novel C3b-binding proteins CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated self-attack
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Mesothelin also known as MSLN is a protein that in humans is encoded by the MSLN gene Cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF) Although it has been proposed that mesothelin may be involved in cell adhesion its biological function is not known A knockout mouse line that lacks mesothelin reproduces and develops normally
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CD8 alpha enhances the responses of antigen-specific CTL activated through TCR through binding MHC class I favoring lipid raft partitioning of TCR and inducing intracellular signaling CD8 alpha is also found on dendritic cells and rat macrophages but whether CD8 alpha enhances responses of a partner receptor like TCR to activate these cells is not known
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ErbB2 also called Neu and Her2 (human epidermal growth factor receptor 2) is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors Upon ERBB2 activation the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
ErbB2 also called Neu and Her2 (human epidermal growth factor receptor 2) is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors Upon ERBB2 activation the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More