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DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC50 of 20 μM. It inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. It can be used in breast cancer and colorectal cancer research.
Potent, competitive, and specific DNA2 nuclease inhibitor
Inhibits nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2
Suitable for breast cancer and colorectal cancer research
Displays strong synergistic effect in inhibiting MCF7 cell survival
Shows synthetic lethality with deficiencies in FEN1, EXO1, or MRE11 genes in mouse model
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An inhibitor of PI4KIIIβ (IC50 = 19 nM); ~100-fold selective for PI4KIIIβ over PI4KIIα, PI4KIIβ, and PI4KIIIα, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, and PI3KC3, as well as 100-500-fold selective over PI3KC2α, PI3KC2β, and PI3KC2γ
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Medchemexpress, HY-19843 5mg MK-0941 CAS:1137916-97-2 MK-0941 is a potent, orally active and allosteric glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 has potential in the treatment of type 2 diabetes. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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