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Pleiotrophin (PTN) is a multifunctional growth factor. The protein coded by the PTN gene is a member of the heparin-binding cytokines family. This gene is located on human chromosome 7. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM) heparin-binding growth factor-8 (HBGf-8) heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSf-1). This gene is highly expressed in brain uterus gut muscle lung and skin. Pleiotrophin mRNA is expressed in osteoblasts chondrocytes tumor cells fibroblasts astrocytes and Schwann cells.
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