Protein Purification
Active Motif 100 mM PMSF
PMSF can be used to prevent protein degradation from serine proteases during sample preparation.
Genscript Corporation CEACAM-5/CD66e 145-322 His
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated
![eMolecules Broadpharm / SPDP-Gly-Gly-methoxy / 100mg / 603111851 / BP-25665 / 98.000 / 2655474-48-7 / [null] / 343.420 / C13H17N3O4S2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480501.JPG-250.jpg)
eMolecules Broadpharm / SPDP-Gly-Gly-methoxy / 100mg / 603111851 / BP-25665 / 98.000 / 2655474-48-7 / [null] / 343.420 / C13H17N3O4S2
Broadpharm / SPDP-Gly-Gly-methoxy / 100mg / 603111851 / BP-25665 / 98.000 / 2655474-48-7 / [null] / 343.420 / C13H17N3O4S2
Genscript Corporation CD4/LEU3 His Avi Human
CD4 also known as L3T4 T4 and W3/25 is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes It is a standard phenotype marker for the identification of T cell populations Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses In T-cells functions primarily as a coreceptor for MHC class II molecule peptide complex
Genscript Corporation CD8 alpha/CD8ABiotin His
CD8 alpha enhances the responses of antigen-specific CTL activated through TCR through binding MHC class I favoring lipid raft partitioning of TCR and inducing intracellular signaling CD8 alpha is also found on dendritic cells and rat macrophages but whether CD8 alpha enhances responses of a partner receptor like TCR to activate these cells is not known
Genscript Corporation CD4/LEU3 His Rhesus macaque
CD4 also known as L3T4 T4 and W3/25 is an approximately 55 kDa type I transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes It is a standard phenotype marker for the identification of T cell populations Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses In T-cells functions primarily as a coreceptor for MHC class II molecule peptide complex
Active Motif MeDIP
The MeDIP Kit is designed to immunoprecipitate and enrich for single-stranded DNA fragments containing 5-methylcytosine (5-mC). The MeDIP Kit contains a monoclonal 5-methylcytidine antibody, a bridging antibody and the necessary buffers to perform methylated DNA immunoprecipitation (MeDIP). The affinity of the antibody enables separation of 5-mC DNA from 5-hmC DNA using single-stranded input DNA. Active Motif's fast, magnetic protocol has been streamlined to minimize the number of wash and incubation steps, saving you valuable time. The kit also includes MseI digested human genomic DNA and PCR primers that can be used to verify the efficiency of the enrichment. Additionally, the kit contains a bar magnet for easy separation and elution of the enriched methylated DNA.
Invivogen TLR9 ANTAGONIST - CLASS B INHI
Toll-Like Receptor 9 (TLR9) detects unmethylated CpG dinucleotides in bacterial or viral DNA inducing strong immunostimulatory effects.TLR9 activation can be mimicked by synthetic phosphorothioate-stabilized oligodeoxynucleotides (ODN) containing immune stimulatory CpG motifs.Studies suggest the existence of DNA sequences that can neutralize the stimulatory effect of CpG ODNs.ODN INH-18 is a linear and class R (restricted) inhibitory ODN. It contains an inhibitory DNA motif consisting of two nucleotide triplets, a proximal CCT and a more distal GGG, spaced from each other by four nucleotides.ODN INH-18 is a potent inhibitor of TLR9-induced B cells and macrophages [1]. ODN INH-18 strongly blocks TLR9 activation in both human and mouse TLR9-expressing cells. INVIVOGEN mfg# TLRL-INH18
Selleck Chemical LLC MG-132 25mg 1211877-36-9
MG132 is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1 ?M and 1.2 ?M for the inhibition of proteasome and calpain, respectively. MG132 activates autophagy and induces apoptosis in tumor cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Bioss KD-Validated Early endosome an
Early Endosome Antigen 1 Primary Antibody Unconjugated Public Immunogen Range 1-63/1411 Host Species Rabbit Target Species Human Mouse Rat Clonality Monoclonal Applications WB FCM IC Concentration Lot dependent Size 50 ul Storage Buffer Supplied in PBS (pH 7 4) containing 50% glycerol and 0 02% sodium azide
Tosoh Bioscience LLC TSKGEL AMIDE-80 2X50 5UM
Column, Normal Phase/Hydrophilic Interaction Chromatography; Tosoh TSKgel Amide-80; Media: Silica; Particle: 5 micrometer; Pore Size: 80 angstrom; 2mm I.D. x 5cm Length; Stainless Steel
AdipoGen IDO1 mouse rec His
Protein. Mouse IDO aa 1-407 is fused at the C-terminus to a His-tag. Source E. coli. Endotoxin content <1EU/µg purified protein LAL test Lonza. Liquid. 0.2µm-filtered solution in 50mM TRIS-Cl, pH 7.4, containing 1mM EDTA. Purity >90% SDS-PAGE. IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic NOD mice, and as a protective negative regulator in autoimmune disorders.
American Research Products Inc Rat Granulocyte Macrophage Col
Rat Granulocyte-Macrophage Colony Stimulating Factor GM-CSF ELISA Kit from CUSABIO Detection Range 15 6 pg/ml - 1000 pg/ml Sensitivity 3 9 pg/ml Sample serum plasma tissue homogenates Method Sandwich
AdipoGen GITRL Soluble hrecHis
Protein. The extracellular domain of human GITRL aa 74-199 is fused at the C-terminus to a His-tag. Source HEK 293 cells. Endotoxin content <0.06EU/µg purified protein LAL test Lonza. Lyophilized from 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. GITRL Glucocorticoid-induced TNF receptor ligand is expressed on dendritic cells DC, monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues e.g. testis. GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
Cayman Chemical PhosphodISTRase 4 InhIbItr 1mg
An inhibitor of PDE4 (IC50 = 0.10 μM for the human recombinant enzyme)