Protein Purification
Medchemexpress LLC 15-LOX-1 inhibitor 1 | 2349374-37-2 | 98.8% | 412.87 | 1 MG
15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. It protects macrophages from lipopolysaccharide-induced cytotoxicity and inhibits NO formation and lipid peroxidation. For research use only.
- Potent inhibitor of 15-LOX-1 (15-lipoxygenase-1)
- Protects macrophages from lipopolysaccharide-induced cytotoxicity
- Inhibits NO formation
- Inhibits lipid peroxidation
- For research use only
Abcam SAHA (Vorinostat), HDAC inhibitor, 10MG
MW 264.32 Da, Purity >98%. Potent non-selective HDAC inhibitor (IC₅₀ values are 10 and 20 nM for HDAC1 and HDAC3, respectively). Induces apoptosis and shows antiproliferative effects against cancer cell lines (IC₅₀ = 3 - 8 μM). Antitumor effects in vivo. No effect on class III HDACs. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam p-Nitropifithrin-alpha, p53 inhibitor, 5MG
MW 398.3 Da, Purity >98%. Cell-permeable p53 inhibitor. Pifithrin-α (ab120478) analog and prodrug. Shows more potent antiapoptotic effects than pifithrin-α. Shows antiobesogenic and hepatoprotective effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical ALK5 InhIbItr II 1mg
A selective inhibitor of the TGF-β type1 receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively); used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription
Cayman Chemical K-Ras G12C InhIbItr 12 5mg
An allosteric inhibitor of oncogenic K-Ras(G12C); decreases viability and increases apoptosis in several lung cancer cell lines that contain G12C mutations (EC50 = 0.32 µM in H1792 cells)
Abcam Batimastat (BB-94), Matrix metalloprotease (MMP) inhibitor
Potent, broad-spectrum MMP inhibitor
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC AC480 (BMS-599626) 5mg 714971-09-2
AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Abcam Aromatase (CYP19A) Inhibitor Screening Kit (Fluorometric)
Aromatase (CYP19A) Inhibitor Screening Kit (Fluorometric)
The product is subject to the following: Abcam Restricted Use Statement
CPC Scientific DABCYL-GABA-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Glu(EDANS)-Ala-Lys-NH2 (trifluoroacetate salt) 0.5MG
Selective fluorogenic matrix metalloproteinase (MMP) substrate with the following Kcat/Km value for MMP-3 (Stromelysiin-1) is 29.0 M-1s-1, for MMP-13 13.0 M-1s-1, and for MMP-9 7.5 M-1s-1 (at pH = 7.5, 25°C). The fluorescence increase is measured using an wavelength of 360 nm and an emission wavelength of 490 nm. No activity against this substrate could be measured with MMP-1, MMP-7, and MMP-8. ONE-LETTER SEQUENCE: Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2MOLECULAR FORMULA: C99H144N28O20S1MOLECULAR WEIGHT:2078.44STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [202273-56-1], RESEARCH AREA: CancerREFERENCES: Beekman, B., et al., 1997. FEBS Lett 418, 305.
STEMCELL Technologies Etoposide, Size: 500 mg
Inhibit proliferation of cancer cells by inhibiting topoisomerase II activity with Etoposide. Highly potent and cell-permeable etoposide inhibits topoisomerase II (IC50 60.3) from religating broken DNA strands by forming a complex with topoisomerase II and DNA which leads to cell death (Wu et al.). Etoposide has also been used as a way to trigger and model cellular senescence in vitro (Bang et al. Te Poele et al. Teng et al. Yang et al.)
Selleck Chemical LLC b-AP15 10mg 1009817-63-3 NSC687852
b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 ?M. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Egfr/ErbB-2-IN-2 | 179248-61-4 | 99.45% | 387.43 | 10 MG
EGFR/ErbB-2-IN-2 is an inhibitor of EGFR and ErbB with IC50s of 0.017 μM, 0.08 μM, and 1.91 μM for EGFR, ErbB-2, and ErbB-4, respectively. It also inhibits c-Src, VEGFR2, and c-Fms with IC50s of 0.30, 2.2, and 14.0 μM, respectively.
- It inhibits EGFR, ErbB-2, and ErbB-4.
- It also inhibits c-Src, VEGFR2, and c-Fms.
- It is for research use only.
Vector Biolabs mouse FOS shRNA Adenovirus (Ad-m-FOS-shRNA)
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown mouse FOS gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this mouse gene was validated by qPCR in by identity cells.
Cayman Chemical IRAK4 InhIbItr 1 10mg
An IRAK4 inhibitor (IC50 = 7 nM); reduces resiquimod-induced increases in TNF-α levels in isolated human PBMCs (EC50 = 300 nM)
Medchemexpress LLC ATP synthase inhibitor 1 | 1023043-30-2 | 99.56% | 411.93 | 10 MG
ATP synthase inhibitor 1 is a potent inhibitor of the c subunit of the F1/FO-ATP synthase complex. It inhibits mitochondrial permeability transition pore (mPTP) opening and does not affect ATP levels. It is intended for research use only.
- Potent inhibitor of the c subunit of the F1/FO-ATP synthase complex
- Inhibits mitochondrial permeability transition pore (mPTP) opening
- Does not affect ATP levels