Protease Inhibitors and Phosphatase Inhibitors
Enzo Life Sciences Pepstatin A (synthetic) (25 mg) CAS: 26305-03-3
Protease inhibitor. Alternative Name: Iva-Val-Val-Sta-Ala-Sta, i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA. Formula: C34H63N5O9. MW: 685.9. CAS: 26305-03-3. MI: 14: 7147. Purity: ≥98% (HPLC). Sequence: i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA. (AHMHA = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid). Appearance: White to off-white solid. Solubility: Soluble in DMSO (10mg/ml), methanol (1mg/ml) or acetic acid. Long Term Storage: -20°C. Use/Stability: Stable for at least 2 years after receipt when stored at -20°C. Handling: Protect from light.
Sigma Aldrich Fine Chemicals Biosciences SUMO Protease His tagged r
SUMO proteases are a general class of enzymes that specifically remove the post-translational protein modification (PTM) known as small ubiquitin-related modifier (SUMO) which falls into the PTM class of ubiquitin and/or ubiquitin-like proteins (UBL). The enzyme commonly referred to as SUMO protease is the Ubl-specific protease 1 (Ulp1) from Saccharomyces cerevisiae. This was the first of this class of enzymes to be isolated. SUMO protease specifically cleaves the SUMO moiety in a scarless manner. SUMO protease recognizes the tertiary structure of the Ubiquitin-like SUMO domain and hydrolyzes the peptide bond in the x-Gly-Gly-x sequence after the Gly-Gly bond at the C-terminus of the SUMO domain. In addition to cleavage of natural SUMO-modified proteins SUMO protease is used to cleave recombinant SUMO fusion proteins. The SUMO domain is a known solubility-enhancing fusion tag used in recombinant protein expression. A histidine tag can also be added at the N-terminus of the SUMO doma
Sigma Aldrich Fine Chemicals Biosciences ReadyShieldR Protease Inhi
This protease inhibitor cocktail has been optimized and tested for mammalian cell and tissue extracts. It contains inhibitors with a broad specificity for serine cysteine acid proteases and aminopeptidases. The cocktail has been tested on extracts from various animal tissues such as human placenta and bovine liver and on extracts of A431 CHO and U937 cells.This cocktail is supplied as a ready-to-use SOLUTIONon using a proprietary non-freezing formulation. ReadyShield PIC0002 is a non-freezing formulation that contains the same inhibitors as is the DMSO based cocktail P8340.
Sigma Aldrich Fine Chemicals Biosciences Akt1/2 kinase inhibitor 985MG
Akt1/2 kinase inhibitor 985MG
Sigma Aldrich Fine Chemicals Biosciences Forskolin, 66575-29-9, MFCD00082317, 10mg
Empirical Formula (Hill Notation) C22H34O7, Molecular Weight 410.50, For use in molecular biology applications, Synonym: 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one, Coleonol, Colforsin
Selleck Chemical LLC SBI-0206965 5mg 1884220-36-3
SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical VEGFR2 KInase InhIbItr I 10mg
A potent, cell-permeable inhibitor of mouse VEGFR2 kinase (IC50 = 70 nM); has little or no effect against PDGFR, EGFR or IGF1R kinases (IC50 > 100 µM)
Selleck Chemical LLC Fludarabine 50mg 21679-14-1 FaraA, Fludarabinum
Fludarabine (FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical PPIase-ParvulIn InhIbItr 5mg
A cell-permeable inhibitor of the PPIases Pin1 and Pin4 (IC50s = 1.5 and 1.0 µM, respectively), interacting with the PPIase domain; blocks the proliferation of cancer cells that overexpress Pin1 and Pin4 (IC50 range = 2-5 µM), and similarly inhibits wild MEFs but not Pin1-/- MEFs
Cayman Chemical Cdk4 InhIbItr 500ug
A cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by selectively blocking cyclin D1/Cdk4 (IC50 = 0.8 μM); inhibits HCT116 and NCI-H460 tumor cell growth (IC50s 1 cell cycle arrest
Invivogen Class B CpG oligonucleotide - Murine TLR9 agonist
Class B CpG oligonucleotide - Murine TLR9 agonist
Cayman Chemical Syk InhIbItr IIhydrochlorI 1mg
A cell-permeable, selective, and reversible inhibitor of Syk (IC50 = 41 nM); prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and inhibits passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.)
Cayman Chemical Akt InhIbItr VIII 1mg
A potent, allosteric inhibitor of Akt1 and Akt2 (IC50 = 58 and 210 nM, respectively) that less effectively blocks Akt3 activity (IC50 = 2.2 µM); cell permeable, blocking insulin regulation of FOXO1 activity at 1 µM in rat hepatoma cells