Protease Inhibitors and Phosphatase Inhibitors
Apexbio Technology LLC Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO), 1ml x 20
Equivalent to Sigma P1860, for use in tissue culture media to prevent proteolytic degradation of secreted proteins. Other sizes are available. Please inqury us for quote.
Supply Solutions Sigma Aldrich - Complete Edta-Free 3 X 20 Tablets * Third Party Item
Sigma Aldrich - Complete Edta-Free 3 X 20 Tablets * Third Party Item
Enzo Life Sciences Anabaenopeptin A (100µg)
Anabaenopeptins are a highly diverse group of bioactive peptides produced by several genera of cyanobacteria such as Anabaena, Planktothrix, Microcystis and Nodularia. These peptides are commonly detected in cyanobacterial blooms along with the well known microcystins. Unique cyclic peptides where lysine is conserved in position 2 and cyclisation is achieved by linkage of the lysine to the C-terminal amino acid. In addition the side chain of a single amino acid is attached via a ureido bond. Bioactive peptides originally isolated from Anabaena flos-aquae NRC 525-17 where they were shown to be non-toxic in mice but had dose dependant relaxations in rat aortic preparations with endothelium precontracted with 0.1µM norpinephrine. Anabaenopeptins inhibit protein phosphatase. Purity: ≥95% (HPLC). Appearance: Pale powder or an oil (film), depending on the lot. Solubility: Soluble in methanol. Long Term Storage: -20°C.
STEMCELL Technologies XAV939, Size: 25 mg
Inhibit tankyrase (TNKS) 1 and 2 with XAV939 (Huang et al. Nature, 2009). By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells (Huang et al. Nature, 2009). This WNT pathway inhibitor inhibits colony formation of APC-deficient, β-catenin-dependent DLD-1 colorectal cancer cells (Huang et al.); induces cardiomyogenesis in mesoderm progenitor cells derived from mouse embryonic stem cells (Wang et al.); and, in combination with the SMAD inhibitors LDN193189 and SB431542, promotes induction of forebrain fates in human pluripotent stem cell lines (Maroof et al.). XAV939 is supplied as a crystalline solid with ≥ 98% purity; Molecular weight 312.3 g/mol; CAS number 284028-89-3. Visit STEMCELL.com for more information and related products.
Cayman Chemical ADAMTS-5 InhIbItr 500ug
An inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1)
Apexbio Technology LLC Irreversible proteasome inhibitor 134381-21-8. MFCD03791061
Irreversible proteasome inhibitor 134381-21-8. MFCD03791061
Research Products International Corp Chymostatin, 5 Milligrams
Reversible serine protease inhibitor of a,b,y, and chymostatin, papain, and cathepsins A,B,C,.
Working concentrations: 10-100uM.
Selleck Chemical LLC Amuvatinib (MP-470) 50mg 850879-09-3 HPK 56
Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFR? and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Echelon Biosciences Research Labs PPlases Substare, fluorogenic - 10 mg, CAS#: 142997-31-7
PPlases Substare, fluorogenic - 10mg , Succinyl-Ala-Leu-Pro-Phe-AMC Category/Application: Enzyme Substrates This item is non returnable
Enzo Life Sciences Chymostatin (5mg). CAS: 9076-44-2
Protease inhibitor. Inhibitor of serine proteinases having a chymotrypsin-like specificity like α-, β-, δ- and γ-chymotrypsin, chymases, cathepsin G, and most cysteine proteinases including papain and cathepsin A, B, H, and L. Mixture of type A (R=L-Leu), type B (R=L-Val), type C (R=L-Ile). Alternative name: (S)-1-Carboxy-2-phenylethyl)-carbamoyl-alpha-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal. Formula: C21H38N4O8. MW: 605.0 (average). Solubility: Soluble in DMSO (20mg/ml) or glacial acetic acid. Long Term Storage: -20°C.
Cayman Chemical BRMBRG1 ATP InhIbItr 1 500ug
A dual inhibitor of BRM and BRG1 ATPase activities (IC50s = <0.005 µM for both); reduces expression of KRT80 in H1299 and RERF-LC-A1 cell lines; reduces tumor cell growth in a RERF-LC-A1 lung cancer mouse xenograft model at 20mg/kg
Cayman Chemical mP-2 InhIbItr II 5mg
An analog of SB-3CT that irreversibly inhibits MMP-2 (Ki = 2.4 µM); less potently inhibits MMP-1 and -7 (Kis = 45 and 379 µM, respectively); attenuates glucose-induced MMP-2 activity and expression, as well as subsequent apoptosis, in retinal endothelial cells
Andwin Scientific 5MG VL MG132 PROTEASOME INHIBI
MG-132 Proteasome Inhibitor, 5mg, White Solid. Carbobenzoxy-l-leucyl-l-leucyl-l-leucinal z-leu-leu-leu-cho. Purity> /=90 by HPLC. Soluble in DMSO, CAS No.: 133407-82-6, MW: 475.6. Potent reversible cell-permeable, 1/EA
Sigma Aldrich Fine Chemicals Biosciences Leupeptin BioUltra, microbial | 103476-89-7 | MFCD00037012 | 5mg
Leupeptin BioUltra, microbial | Purity: 0.95 | 475.59 | 103476-89-7 | MFCD00037012 | 5mg
Cayman Chemical nDD8 InhIbItr M22 5mg
An inhibitor of NEDD8-activating enzyme; inhibits NEDDylation of UBC12 in a cell-free assay using recombinant human NAE; selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 cells; inhibits the growth of A549 cells (GI50 = 5.5 µM); inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model at 60 mg/kg