Protease Inhibitors and Phosphatase Inhibitors
CPC Scientific Z-Val-Phe-CHO 1MG
Potent and cell permeable calpain I and II inhibitor that reduces capsaicin-mediated cell death in cultured dorsal root ganglionand. This peptide is additionally a gamma-secretase-inhibitor that reduces occurrence of apoptosis in H2O2 and A23187 treated PC12 cells.ONE-LETTER SEQUENCE: Z-VF-CHOMOLECULAR FORMULA: C22H26N2O4MOLECULAR WEIGHT:382.5STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [88191-84-8], RESEARCH AREA: Apoptosis
Abcam Camostat mesylate, TMPRSS2 inhibitor, 10MG
MW 494.52 g/mol, Purity >98%. Trypsin-like protease inhibitor. Reversibly inhibits airway epithelial sodium channel (ENaC) function (IC₅₀ = 50 nM). Inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes and disrupts proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis. Inhibits transmembrane serine protease TMPRSS2 and blocks entry of SARS-Cov-2 into lung cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam HA 100 dihydrochloride, Myosin light chain kinase, PKA, PKC and PKG inhibitor, 50MG
MW 313.8 Da, Purity >98%. HA 100 dihydrochloride, Myosin light chain kinase, PKA, PKC and PKG inhibitor.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical SIRT12 InhIbItr IV 25mg
A cell-permeable inhibitor of SIRT1 (IC50 = 56 µM) and SIRT2 (IC50 = 59 µM); less effectively inhibits SIRT5 (IC50 >300 µM) and has no effect on class I and II HDACs; sensitizes H460 lung cancer cells to etoposide and paclitaxel; blocks a SIRT1-dependent hypoxic response in vivo
TARGETMOL CHEMICALS INC DARUNAVIR 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone it is administered in combination with other ANTI-HIV AGENTS. purity: 99%
Abcam PRL-3 Inhibitor I, 25MG
MW 485.2 Da, Purity =98%. A potent inhibitor of PRL-3, IC₅₀=0.9 μM. Sensitizes PRL-3-expressing cancer cells to chemotherapeutics. Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells. Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences Pepstatin A | 26305-03-3 | | 10MG
Pepstatin A | Purity: 100,000 U/mg | Mol Wt: 685.89 | 26305-03-3 | | 10MG
Selleck Chemical LLC FGFR1/DDR2 inhibitor 1
FGFR1/DDR2 inhibitor 1 is an inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoidin domain receptor 2 (DDR2)
Cayman Chemical PTP InhIbItr II 25g
A cell-permeable inhibitor of the catalytic domain of SHP-1, SHP-1(ΔSH2) (Ki = 128 µM)
Cayman Chemical JAK2 InhIbItr V 25mg
A selective inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2, displaying IC50 values between 10 and 30 µM; blocks the proliferation of erythroleukemia cells and human hematopoietic progenitor cells expressing JAK2-V617F
Abcam Topotecan hydrochloride (SKF 104864), Topoisomerase inhibitor, 50MG
MW 457.9 Da, Purity >98%. Topoisomerase I inhibitor. Water-soluble derivative of camptothecin (ab120115). Anticancer agent.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Importazole, nuclear transport receptor importin-beta inhibitor, 25MG
MW 318.42 g/mol, Purity >99%. Selective nuclear transport receptor importin-β inhibitor (IC₅₀ = 25 μM). Blocks SINC localization at the nuclear envelope. Impairs release of importin-β cargo and induces defects in defects in spindle assembly during mitosis.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical PKR InhIbItr 10mg
Binds the ATP-binding site of PKR and blocks autophosphorylation (IC50 = 186-210 nM); protects neuroblastoma cells against cell damage triggered by ER stress; prevents phosphorylation of FADD, preventing apoptosis; reduces phosphorylation of PKR and eIF2α in the brain, enhancing long-term memory storage
Cayman Chemical ENPP3 InhIbItr 4t 25mg
An ENPP3 inhibitor (IC50 = 0.15 µM); selective for ENPP3 over ENPP1 (IC50 = 41.4 µM)
Selleck Chemical LLC Motesanib Diphosphate (AMG-706) 10mg 857876-30-3
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit (c-Kit), ~10-fold more selective for VEGFR than PDGFR and Ret. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.