Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ SB 220025
A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60nM).
MilliporeSigma™ Calbiochem™ PKM2 Activator III
A cell-permeable quinoline-sulfonamide that acts as a potent allosteric PKM2 activator both in cell-free enzymatic assays (AC50 = 17nM with 40 ng PKM2/200μL) and in cultures (AC50 = 45nM in A549 cells) via a high affinity, 2:1 stoichiometric binding, effectively locking PKM2 in an active tetrameric state resistant to known intracellular negative regulators of FBP-activated PKM2 te
MilliporeSigma™ Calbiochem™ Isogranulatimide
Isogranulatimide, also referenced under CAS 244148-46-7, modulates the biological activity of Chk1 and GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ GSK-3beta Inhibitor XXVII, CESI
A cell-permeable, 3-hydroxychromone derived compound that acts as a selective and reversible inhibitor of GSK-3β (IC50 < 100
MilliporeSigma™ Calbiochem™ ADAMTS-5 Inhibitor
The ADAMTS-5 Inhibitor, also referenced under CAS 929634-33-3, controls the biological activity of ADAMTS-5. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ TGF-β RI Kinase Inhibitor IX
A cell-permeable pyridinyloxypyridine compound that acts as a potent and highly selective inhibitor against TGFβ RI/ALK5 (IC50 = 72 nM, [ATP] = 1 mM) by targeting both the ATP-binding site and the selectivity pocket, while exhibiting much reduced or little activity against a panel of 75 other kinases (IC50 <1μM).
MilliporeSigma™ Calbiochem™ Ifenprodil Hemitartrate
A partial non-competitive antagonist highly selective for GluN1/N2B subtype NMDA receptors (IC50
MilliporeSigma™ Calbiochem™ BAY 11-7085
Has biological properties very similar to those of BAY 11-7082. In addition, BAY 11-7085 shows potent anti-inflammatory properties in vivo.
MilliporeSigma™ Calbiochem™ TGF-β RI Kinase Inhibitor V
The TGF-β RI Kinase Inhibitor V, also referenced under CAS 627536-09-8, controls the biological activity of TGF-β RI. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ NSC 721648
A cell-permeable benzothiazole compound that exhibits potent in vitro antiproliferative activity against HCC 2998, IGROV1, MCF-7, MDA 468, SR, and T-47D.
MilliporeSigma™ Calbiochem™ A-803467
A voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC50) = 140 nM).
MilliporeSigma™ Calbiochem™ Galectin-1 Antagonist, DB21
A dibenzofuran conjugated peptidomimetic (13-mer) that acts as an allosteric inhibitor of galectin-1 binding to cell surface glycans (IC50 = 3
MilliporeSigma™ Calbiochem™ Okadaic Acid, Prorocentrum sp.
Okadaic Acid, CAS 78111-17-8, is a highly potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and 2A (IC50 = 0.1 nM).
MilliporeSigma™ Calbiochem™ Rapamycin
Rapamycin, CAS 53123-88-9, is an immunosuppressant that selectively inhibits mTOR and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM).