Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Rottlerin
Rottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ(IC50= 3-6μM) and PKCθ. Has about 10-fold lower potency against other isozymes.
MilliporeSigma™ Calbiochem™ Sodium 4-Phenylbutyrate
A novel anti-neoplastic agent and transcriptional regulator.
MilliporeSigma™ Calbiochem™ STAT5 Inhibitor III, Pimozide
The STAT5 Inhibitor III, Pimozide, also referenced under CAS 2062-78-4, controls the biological activity of STAT5.
MilliporeSigma™ Calbiochem™ Simvastatin
A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation.
MilliporeSigma™ Calbiochem™ InSolution™ Sirtinol
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity
MilliporeSigma™ Calbiochem™ Spermidine, Trihydrochloride
Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.
MilliporeSigma™ Calbiochem™ SMER28
A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures
MilliporeSigma™ Calbiochem™ Sirtinol
A cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1.
MilliporeSigma™ Calbiochem™ SU6656
A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor.
MilliporeSigma™ Calbiochem™ STAT3 Inhibitor VII
The STAT3 Inhibitor VII, also referenced under CAS 1041438-68-9, controls the biological activity of STAT3.
MilliporeSigma™ Calbiochem™ Sulindac Sulfide
A cell-permeable, active metabolite of Sulindac.
MilliporeSigma™ Calbiochem™ SU1498
A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC50 = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase.
MilliporeSigma™ Calbiochem™ STAT3 Inhibitor V, Stattic
STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.
MilliporeSigma™ Calbiochem™ SB 202190, Hydrochloride
A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.
MilliporeSigma™ Calbiochem™ Shikonin
A naphthoquinone found in the Chinese herb Shiunko.