Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Ibotenic Acid
A highly potent agonist of NMDA and mGlu receptors.
MilliporeSigma™ Calbiochem™ PI 3-Kγ Inhibitor II
The PI 3-Kγ Inhibitor II, also referenced under CAS 648449-76-7, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ NF-κB Activation Inhibitor II, JSH-23
The NF-κB Activation Inhibitor II, JSH-23, also referenced under CAS 749886-87-1, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
MilliporeSigma™ Calbiochem™ Late Endosome Trafficking Inhibitor, EGA
A cell-permeable compound that prevents various bacterial toxins from exerting their cytotoxic activity by blocking endosomal trafficking/maturation into acidified late endosomes.
MilliporeSigma™ Calbiochem™ Histone Acetyltransferase Inhibitor IV, CPTH2
A cell-permeable thiazolyl-hydrazone compound that inhibits the acetylation of histone H3 by recombinant human Gcn5 in a substrate-competive manner, while exhibiting little activity against rhGcn5 autoacetylation
MilliporeSigma™ Calbiochem™ Guanosine 3',5'-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt
A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II.
MilliporeSigma™ Calbiochem™ CFTR Inhibitor II, GlyH-101
CFTR Inhibitor II, GlyH-101, CAS 328541-79-3, is a cell-permeable potent, selective and reversible open-channel blocker of CFTR (Ki = 4.3 μM in CFTR-expressing FRT cells).
MilliporeSigma™ Calbiochem™ GSK-3β Peptide Inhibitor, Cell-permeable
The GSK-3β Peptide Inhibitor, Cell-permeable controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ β-Secretase Inhibitor III
The β-Secretase Inhibitor III controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
MilliporeSigma™ Calbiochem™ mGlu7 Antagonist, XAP044
A blood-brain barrier permeable, potent, selective, and reversible antagonist of mGlu7 receptor (IC50 = 3.5 and 2.8 μM for mGlu7a and mGlu7b in CHO cells).
MilliporeSigma™ Calbiochem™ VEGF Inducer, GS4012
A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation.
MilliporeSigma™ Calbiochem™ Latrunculin B, Latrunculia magnifica
A structurally unique marine toxin. Inhibits actin polymerization
MilliporeSigma™ Calbiochem™ Necrostatin-1
Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α).
MilliporeSigma™ Calbiochem™ 2-Guanidinoethylmercaptosuccinic Acid
Potent inhibitor of a carboxypeptidase B-like processing enzyme referred to as enkephalin convertase (Ki = 8.8 nM).
MilliporeSigma™ Calbiochem™ AP-1/NF-κB Dual Inhibitor, SP100030
A cell-permeable, non-toxic, conformationally restricted pyrimidinecarboxamide compound that acts as a potent, reversible T-cell specific inhibitor of both AP-1 and NF-κB transcriptional activation (IC50 = 50