Collagens
Cayman Chemical IcarIsIde I 10mg
A flavonoid glycoside; stimulates the proliferation and differentiation of isolated rat osteoblasts in a concentration-dependent manner; increases the cytotoxicity of adriamycin in multidrug-resistant MCF-7/adr breast cancer cells (IC50 = 60.78 µM)
Biolegend Purified anti-P-Cadherin
Purified anti-P-Cadherin [12H6]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: WB, IP; Size: 100 μg
Cayman Chemical 15 16-DIhydrotnshInon I 5mg
A diterpene tanshinone with diverse biological activities; inhibits RHL-2H3 mast cell degranulation (IC50 = 14.3 μM); prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM); inhibits the production of TNF mRNA and protein in MCF-7 cells; reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells (IC50s = 0.84, 0.92, and 1.2 μM, respectively); reduces collagen-induced aggregation of washed rabbit platelets (IC50 = 8.7 μM); reduces HL-60 leukemia tumor growth in a mouse xenograft model by 68% at 25 mg/kg; increases latency to step-through in a passive avoidance test in mice with scopolamine-induced learning and memory impairment at 2-4 mg/kg, p.o.
ABclonal Technology p-PKC alpha/beta II-T638/T641
Protein kinase C (PKC) is a family of serine- and threonine-specific kinases activated by calcium and diacylglycerol PKC family members phosphorylate various protein targets and are involved in multiple cellular signaling pathways They also serve as receptors for phorbol esters tumor-promoting compounds Each PKC member has a distinct expression profile and role in cells The protein encoded by this gene is a PKC family member involved in B cell activation apoptosis endothelial cell proliferation and intestinal sugar absorption Studies in mice suggest it may also regulate neuronal functions and influence fear-induced behavior after stress Alternative splicing generates distinct isoforms of this gene
FUJIFILM BIOSCIENCES INC Laminin sol from Mouse EHS Tum
Laminin is a glycoprotein with a molecular weight of approximately 900 kDa found in the basement membrane of most tissues It is composed of three chains a1 1 and 1 It binds to collagen type IV and heparan sulfate playing a crucial role in the structure and function of the basement membrane In cell culture it primarily mediates adhesion between epithelial cells endothelial cells and hepatocytes and also promotes axonal outgrowth in neurons as well as differentiation and chemotaxis It is closely associated with cancer metastasis and highly metastatic cancer cells are known to express a high number of laminin receptors on their cell surfaces