Collagens
Cayman Chemical CItrulInated Colagen TYP I
An HCV NS5A inhibitor inhibits HCV replication in stable replicon cell lines containing NS5A from genotypes 1a -1b -2a -3a -4a and -5a (EC50s 2-24 pM) acts additively with IDX184 TMC647055 or simeprevir to inhibit viral replication in genotype 1b HCV replicon cells
Cayman Chemical Endosulfn I 100mg
A sesquiterpene with diverse biological activities an agonist of the CB2 receptor (Ki 155 nM) that inhibits forskolin-induced cAMP production in CHO-K1 cells expressing CB2 receptors (EC50 38 nM) an agonist of PPARa (EC50 9.58 UM in a reporter assay) reduces MPP -induced production of ROS in and protects against cytotoxicity of SH-SY5Y cells at 1 and 2.5 UM decreases theBamyloid burden in the hippocampus and cerebral cortex and improves memory in an APP/PS1 transgenic mouse model of Alzheimers disease at 48 mg/kg has anxiolytic-like and antidepressant-like activity in mice at 50 mg/kg
Cayman Chemical ZIyuglycosIde I 10mg
A stimulator of sGC stimulates the formation of cGMP in CHO cells expressing recombinant rat sGC in the absence and presence of SNAP (EC50s 1005 and 39 nM respectively) an effect that can be reversed by ODQ inhibits phenylephrine-induced contractions in isolated rabbit saphenous artery rings rabbit aortic rings and canine femoral vein rings (IC50s 798 692 and 3072 nM respectively) decreases the coronary perfusion pressure in isolated perfused rat hearts decreases proteinuria and increases survival in an (mRenR2)27 transgenic rat model of hypertension at 3 or 10 mg/kg
Cayman Chemical CoryncIn IV 1mg
A DPP-4 inhibitor (IC50 1.6 nM) selective for DPP-4 over several proteases including DPP-7 DPP-8 DPP-9 and FAP (IC50s 67 UM for all) as well as the ion channels Ikr Cav1.2 Nav1.5 (IC50 30 UM for all) and a panel of 168 enzymes (IC50s 10 UM for all) reduces blood glucose levels by 51 in mice at 0.3 mg/kg
Cayman Chemical 15 16-DIhydrotnshInon I 10mg
A monoterpene with anti-inflammatory activity stimulates proliferation of lymphocytes derived from allergic patients in vitro at 6.2 and 62 Ug/ml decreases scratching behavior and reduces skin thickness in a mouse model of atopic dermatitis when administered topically at 0.1-10 UM decreases serum IgE levels and skin protein levels of inflammatory cytokines including IFN-Y IL-6 IL-1B TNF-a and NF-KB in skin
Sigma Aldrich Fine Chemicals Biosciences Collagen calf skin Bo100MG
Collagen type I is a component of skin, bone, tendon, and other fibrous connective tissues. It is a left handed helix with three polypeptide chains and contains repeating units of glycine, proline and hydroxyproline amino acids. It is a component of extracellular matrix and close to 28 types is present in bovine.
Cayman Chemical ProstaglndIn I MetabolIte480
A conotoxin and an inhibitor of Nav1.4 receptors inhibits Nav1.4 in HEK293 cells (IC50 2.3 nM for the rat channel) inhibits rat Nav1.2 channels in HEK293 cells at 500 nM and is an antagonist of a7 nAChRs and a4B2 and a3B2 subunit-containing nAChRs in Xenopus oocytes expressing the human receptors (IC50s 22 2.9 and 0.45 UM respectively) reduces global nerve action potential in isolated mouse sciatic nerves in a concentration-dependent manner inhibits contraction in isolated mouse hemidiaphragm muscles (IC50 46 nM)
Cayman Chemical ProstaglndIn I MetabolIte480
INDIGOs assay kits provide the convenience of an all-inclusive cell-based assay system. In addition to ADRB3 Reporter Cells provided are two optimized media for use in recovering the cryopreserved cells and for diluting test samples the reference activator Isoproterenol Luciferase Detection Reagents and a cell culture-ready assay plate.
ILEX LIFE SCIENCES LLC Collagen-I (Type I Collagen) Mouse Native Protein (Tail Tendon), 1 mg
Native Mouse Collagen-I is a natural protein purified from mouse tail tendon. Purity greater than 90%. FORMULATION: Filtered and lyophilized without additives. OTHER NAMES: Murine Type 1 Collagen, Type I Collagen, Collagen-1. SUMMARY: Collagen, a major extracellular matrix (ECM) component, is a fibrous protein that provides tensile strength to tissues giving them structural integrity. Collagens contribute to mechanical properties, organization, and shape of tissues. Collagen is the most widely used ECM protein for cell culture, facilitating cell attachment, growth, differentiation, migration, and tissue morphogenesis. Type I Collagen is by far the most abundant protein in all vertebrates. It assembles into fibers that form the structural and mechanical scaffold (matrix) of bone, skin, tendons, cornea, blood vessel walls and other connective tissues. Type I collagen consists of two ?1(I) chains and one ?2(I) chain.
ILEX LIFE SCIENCES LLC Promed Bioscience Atelocollagen Ultrapure, Porcine Type I, Enzymatic extraction, dialyzed, lyophilized, 10 mg
Atelocollagen Ultrapure, Porcine Type I, Enzymatic Extraction, Dialyzed, Lyophilized. Characterized by rich and ultra dialysis-purified Type I collagen content in a regular fibril-like configuration that retains its superior functionality and structural properties. The proprietary pepsin enzyme-based extraction removes telopeptides at the nonhelical N and C termini, resulting in a triple helix configuration that exhibits reduced immunogenicity. APPLICATION: Biocompatible and biodegradable, suitable for many research applications, such as bioink for 3D bioprinting, in vitro cell culture, cell functional assays, etc. MANUFACTURER: Promed Bioscience Ltd. CAS NO.: 9007-34-5. PURITY: greater than 97%. SOURCE: Porcine tendon. AMINO ACID ANALYSIS: Typical profile. STERILITY TESTING: Pass (0 cfu/g). STERILIZATION METHOD: Produced under strict aseptic conditions. CELL ATTACHMENT ASSAY: Pass. CELL TOXICITY ASSAY: Pass. OTHER NAMES: Type 1 Collagen, Collagen-1.