Measure binding of small molecule drug candidates to target protein in a cellular environment with Alpha CETSA target engagement assays. For use in combination with Pelago Bioscience's CETSA (Cellular Thermal Shift Assay) technology, this kit provides a convenient no-wash assay for detection and quantitation of small molecule binding to BCL-2, and can be used in hit identification, hit confirmation, and lead optimization studies for increased confidence and better prediction early in the drug discovery process. Please note that a valid CETSA subscription from Pelago Biosciences is required for use.