Cayman Chemical ANTIBODY VP-14637 1mg
A PDE4 inhibitor (IC50 0.8 nM) selective for PDE4 over PDE1 -2 -3 and -5 (IC50s 10 10 10 and 8 UM respectively) inhibits fMLP-induced LTB4 production in isolated human neutrophils (IC50 2 nM) reduces the proliferation of anti-CD3 and anti-CD28-stimulated isolated human CD4 T cells (IC30 7 nM) prevents pulmonary inflammatory cell infiltration and emphysema in mice exposed to cigarette smoke at 5 mg/kg