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L-alpha-Phosphatidylcholine (Egg, Chicken), Hygroscopic as lyophilized powder, C 42 H 82 NO8P, Percent composition: C 66.37% H 10.87% N 1.84% O 16.84% P 4.08%, 1g
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DPPE-PEG2000 ammonium is a PEG-modified phosphatidylethanolamine used in research to impart steric stabilization to liposomes and other lipid-based delivery systems. It reduces nonspecific protein adsorption and can prolong circulation time, and is commonly used in liposome preparation and in the formulation of PEG-MLPs and magnetoliposomes.
Reduces nonspecific protein adsorption on particle surfaces
Prolongs circulation time of lipid-based formulations
Suitable for liposome and lipid nanoparticle preparation
Available in small research quantities for formulation work
High purity (reported ~99.8%) and average molecular weight ~2700 Da
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An ionizable cationic (pKa = 6.38) and biodegradable lipid derivative of DLin-MC3-DMA; has been used in the formation of LNPs; administration of mouse FVII-targeting siRNA in L-319-containing LNPs reduce serum levels of FVII in mice; LNPs containing L-319 in combination with cKK-E12 and encapsulating VZV mRNA encoding gE increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA, in a guinea pig model of VZV-induced shingles
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DMG-PEG2000-MAL is a polyethylene glycol (PEG) derivative functionalized with dimyristoyl glycerol (DMG) and a terminal maleimide (MAL) group The maleimide moiety readily reacts with thiol (-SH) groups present on biomolecules forming stable covalent thioether bonds This reaction facilitates site-specific conjugation or labeling of proteins peptides and other thiol-containing biological structures DMG-PEG2000-MAL is widely utilized in biomedical research particularly in formulating lipid-based drug delivery platforms such as siRNA-loaded liposomes and lipid nanoparticles (LNPs)
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