Antibody-Binding Proteins and Conjugates
Jackson Immuno Research Labs Cy3-ChromPure Rabbit IgG whole molecule
Cy3-ChromPure Rabbit IgG whole molecule
Jackson Immuno Research Labs Alexa Fluor 594-ChromPure Sheep IgG whole molecule
Alexa Fluor 594-ChromPure Sheep IgG whole molecule
Columbia Biosciences Corp GT ANTI-GST DYLIGHT 488 100UG
Goat Anti-GST IgG, primary antibody, conjugated to DyLight 488, 100ug. Microscopy, Flow Cytometry and Cell Based Assays
Cayman Chemical ParecoxIbsodIum salt 50mg
A prodrug form of valdecoxib; converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys; a CB1 agonist (EC50 = 2.4 µM in HEK293 cells); reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg)
Cayman Chemical OlsalazInsodIum salt 500mg
A prodrug form of 5-ASA; increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50 = 0.3 mM); stimulates fluid transport in rat jejunum (5 mM); improves stool consistency and decreases occult and gross bleeding as well as MPO activity and LTB4 levels in colon tissue in a mouse model of dextran sulfate-induced colitis (150 mg/kg for 8 days); inhibits bovine xanthine oxidase in vitro (IC50 = 3.4 mg/L); lowers serum uric acid levels in an oxonic acid-induced mouse model of hyperuricemia (20 mg/kg)
Cayman Chemical TalaporfInsodIum salt 50mg
A photosensitizer; induces apoptosis, DNA DSBs, and the production of ROS in TE-11R 5-fluorouracil-resistant cells at 30 UG/ml in combination with radiation; reduces tumor growth in a TE-11R ESCC mouse xenograft model at 2.5, 5, and 10 mg/kg in combination with PDT
Abcam Ale x a Fluor 594 Conjugation Kit (Fast) - Lightning-Link, 1MG
Alexa Fluor 594 conjugation / labeling in < 20 mins with 30 secs hands-on time using Alexa Fluor 594 Conjugation Kit (Fast) - Lightning-Link ab269822. 100% antibody recovery.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical PIrIprostpotasIum salt 50mg
Piriprost is a structural analog of PGI2 with low IP receptor-mediated activity. Piriprost inhibits 5-LO with an IC50 value around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.{994} Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 value of 0.11 µM.{4708}
Cell Signaling Technology WHITLOW/218 LINKER(E3U7Q)RAB,
Whitlow/218 Linker (E3U7Q) Rabbit mAb (PE Conjugate) #62405100ul
MORADEC LLC Fab-αHFc-CL-DMDM, 50 μg, Human IgG Fc region specific, Cleavable linker, Alkylates DNA
Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker is a specialized secondary antibody-drug conjugate designed for research applications. This product uniquely combines the Fab fragment of a polyclonal antibody with Duocarmycin DM, a cytotoxic small molecule, to facilitate targeted cell death through DNA alkylation. The cleavable linker ensures stability in extracellular environments and offers selective activation within cells for enhanced delivery of therapeutic agents. This approach creates opportunities for innovative antibody lead screening in ADC development.
- Target specificity for the human IgG Fc region
- Monovalent nature of the Fab fragment
- Stability in extracellular fluid
- Cleavable linker activated by intracellular cathepsins
- Alkylation mechanism targeting DNA minor groove
- Suitable for antibody pre-screening applications
- 50 μg quantity available