Antibody-Binding Proteins and Conjugates
Cayman Chemical EtIdronatesodIum salt 500mg
An affinity probe which allows carbaprostacyclin to be detected in complexes with transmembrane receptors and/or nucleic or protein binding partners
Cayman Chemical PIperacIlInsodIum salt 500mg
A potent inhibitor of class I PI3K isoforms (IC50 values of 5 27 7 and 14 nM for PI3Ka B and Y respectively) and mTOR (Ki 17 nM) induces cell cycle arrest or apoptosis in a range of cancer cell lines effective in vivo suppressing the growth of a number of tumor xenografts in mice
Cayman Chemical BCIPp-toluIdIn salt 500mg
An internal standard for the quantification of hydralazine by GC- or LC-MS
Cayman Chemical MaduramIcInamonIum salt 50mg
A cereblon modulator binds to cereblon (IC50 0.03 UM in a FRET assay) and induces the degradation of Ikaros and Aiolos in H929 R10-1 at 1 10 and 100 nM induces apoptosis in the same cells reduces tumor growth in an H929 R10-1 mouse xenograft model at 1 3 and 10 mg/kg
Cayman Chemical BatbulInsodIum salt 50mg
A CXCR4 antagonist (IC50 0.91 nM) inhibits HIV-1-induced cytopathogenicity in MT-4 cells (EC50 4 nM) reduces CXCL12-induced migration of SUP-T1 leukemia and MDA-MB-231 at 100 nM induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells at 8 and 40 UM reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model reduces the incidence of arthritis in a mouse model of collagen-induced arthritis
Cayman Chemical FosInoprIlsodIum salt 50mg
An internal standard for the quantification of cholic acid by GC- or LC-MS
Cayman Chemical ArachIdIc AcIdodIum salt 50mg
An internal standard for the quantification of tenofovir by GC- or LC-MS
Cayman Chemical MItIglInIdecalcIum salt 50mg
An activator of autophagy inhibits mTORC1 signaling by covalently binding to the lysosomal v-ATPase selective for inhibition of mTORC1 over mTORC2 signaling increases lysosome acidification and increases cellular clearance of TDP-43 protein aggregates in a v-ATPase-dependent manner in U2OS osteosarcoma cells inhibits mTORC1 signaling and enhances autophagy in mouse skeletal muscle and heart at 50 mg/kg
Cayman Chemical TInptInsodIum salt 500mg
A cell-permeable inhibitor of SCF-mediated c-kit activation completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 UM prevents SCF-mediated downstream phosphorylation of p44/p42 ERK
Cayman Chemical AzlocIlInsodIum salt 500mg
A potent antagonist of the PAF receptor inhibiting aggregation of rabbit and human platelets induced by PAF with IC50 values of 75 and 170 nM respectively prevents PAF-induced hypotension in rats while not blocking hypotension triggered by arachidonic acid histamine bradykinin or isoproterenol
Cayman Chemical CefonIcIdodIum salt 500mg
An inactive major metabolite of methylphenidate intended for forensic and biological research purposes
Cayman Chemical PIrIprostpotasIum salt 50mg
PGF2a tromethamine salt is a crystalline derivative of PGF2a with increased water solubility. Its solubility in PBS is 25 mg/ml compared to 10 mg/ml for PGF2a.
Cayman Chemical DIdodIum salt 50mg
A natural phytochemical that has anti-cancer effects at least in part through inhibition of NF-KB and Akt signaling pathways
Cayman Chemical 1-thIoD-GlucosesodIum sa 500mg
An a-methylated analog of 2C-B-FLY and the dihydrofuran analog of DOB a potent agonist of 5-HT2A and 5-HT2C intended for forensic and research purposes