Native Proteins and Derivatives
Cayman Chemical CalpaIn InhIbItr II 25mg
A potent PLD2 inhibitor both in vitro (IC50 140 nM) and in cells (IC50 110 nM) also effective as a PLD1 inhibitor at higher concentrations (IC50 5.1 M in vitro 1.0 M in cells) strongly inhibits the invasive migration of breast cancer cells in transwell assays
Cayman Chemical UbIquItInlIkSpecIfIc Prote
An aglycone with diverse biological activities inhibits the proliferation and migration of A549 H1299 H1975 and SK-MES-1 lung cancer cells from 10-50 UM induces AMPK activation and autophagy as well as apoptosis and cell cycle arrest at the G1 phase in A549 cells at 50 UM reduces tumor weight and volume in an A549 mouse xenograft model at 10 mg/kg reduces colonic inflammatory cell infiltration and colonic shortening in a mouse model of DSS-induced ulcerative colitis at 5 mg/kg improves LPS-induced memory impairments and decreases hippocampal and frontal cortex levels of TNF-a IL-1B and IL-6 in LPS-challenged mice
A8953-500ul Neutrophil Elastas
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin Humans have six elastase genes which encode structurally similar proteins The encoded preproprotein is proteolytically processed to generate the active protease Following activation this protease hydrolyzes proteins within specialized neutrophil lysosomes called azurophil granules as well as proteins of the extracellular matrix The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin This protein also degrades the outer membrane protein A (OmpA) of E coli as well as the virulence factors of such bacteria as Shigella Salmonella and Yersinia Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN) This gene is present in a gene cluster on chromosome 19
Cayman Chemical 3OMethylgunosIn5OtrI 2.7mg
A lignan scavenges ABTS radicals in a cell-free assay (IC50 19.4 UM) inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 84.45 UM) inhibits AB42 self-aggregation in a cell-free assay at 20 UM
Cayman Chemical Nat-20 S-yn 1mg
A positive allosteric modulator of 5-HT2A and 5-HT2C receptors selective for these receptors over a panel of 21 receptors and transporters at 10 UM enhances 5-HT-induced calcium release in CHO cells expressing recombinant human 5-HT2A or 5-HT2C at 1 nM reduces spontaneous locomotor activity in rats at 30 mg/kg
AdipoGen Clusterin SF hrec
Protein. Signal peptide sequence and the human secretory clusterin aa 1-449 are fused at the C-terminus to a FLAG -tag. Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Purity >90% SDS-PAGE. Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80kDa disulfide-linked heterodimer of alpha and beta subunits produced by internal cleavage. Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling and immune system regulation. Clusterin also exists as a nuclear protein.
GENOMEDITECH SHANGHAI CO LTD BIOTINYLATED HUMAN OX40L PROTE
NC3790012 BIOTINYLATED HUMAN OX40L PROTE
Biotium MAP3K1 Mitogen-Activated Protein Kinase Kinase Kinase 12F6 CF647 conjugate 0.1mgmL
MAP3K1 Mitogen-Activated Protein Kinase Kinase Kinase 12F6 CF647 conjugate 0.1mgmL
ABclonal Technology APOE Rabbit mAb
The protein encoded by this gene is a major apoprotein of the chylomicron It binds to a specific liver and peripheral cell receptor and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes Mutations in this gene result in familial dysbetalipoproteinemia or type III hyperlipoproteinemia (HLP III) in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants