API-1 is a small-molecule, selective Akt/PKB inhibitor used in research to probe Akt signaling, apoptosis, and cell proliferation. It binds the pleckstrin homology (PH) domain to inhibit Akt membrane translocation, lowers phosphorylated Akt levels, and is supplied as a high-purity reagent for in vitro studies.
- Selective Akt/PKB inhibition for pathway studies.
- Binds the pleckstrin homology (PH) domain.
- Reduces phosphorylated Akt and cell proliferation in assays.
- High purity (≈99.6%) suitable for biochemical experiments.
- Small package sizes available for screening and pilot studies.
- Molecular weight 337.29 g/mol; formula C13H15N5O6.