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AP50 Mouse, Unlabeled, Clone: 31, BD

Mouse Monoclonal Antibody

$225.00 - $450.00


Antigen AP50
Isotype IgG1
Immunogen Mouse AP50/μ2 aa. 110-230
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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BD Biosciences
150μg Each for $450.00
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BD Biosciences
50μg Each for $225.00
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Sorting of integral membrane proteins is mediated vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (γ, α, δ, ε, and β1, β2, β3, β4 respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, µ4 respectively) and one small chain ( σ1, σ2, σ3, σ4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2, µ2 (AP50) interacts with integral membrane proteins via binding to tyrosine-based signals with the canonical motif YXXφ. In addition, AP50/µ2 is required for both the assembly and the proton transport activity of vacuolar (H+)-ATPases in clathrin coated vesicles. Thus, AP50/µ2 may be involved in targeting integral membrane proteins that are sorted based on tyrosine-based signals and involved in assembly of functional ion channels associated with clathrin coated vesicles.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse AP50/µ2 aa. 110-230
Formula Weight [Chemical]: 50kDa

Immunofluorescence, Western Blotting



Mouse AP50/μ2 aa. 110-230
Cell Biology
Affinity Purified
Store undiluted at -20°C.
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Western Blot

For Research Use Only.

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