APP-BP1 Mouse, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB611864	BD Biosciences 611864	50 μg
BDB611865	BD Biosciences 611865	150 μg

Description

Amyloid precursor protein (APP) gene encodes multiple APPs ranging from 695 to 770 amino acids. These proteins are processed into β-Amyloid peptides (39-43 amino acids), which form abnormal plaques in the cerebral cortex and blood vessel walls during Alzheimer's disease. The transmembrane form of APP is a putative cell surface receptor that possesses neurite-promoting activity, co-localizes with the plaques found in Alzheimer's disease, and is involved in synaptic vesicle recycling. APP binding protein 1 (APP-BP1) interacts with the C-terminus of APP, and is a relative of the ubiquitin-activating enzymes (E1). The structure of APP-BP1 includes a human Uba3 binding site (UBS) at amino acids 443 to 479. This site may be important for APP-BP1 regulation of the cell cycle through interactions with ubiquitinylation-related pathways. Transfection of APP-BP1 in cells with a ts41 mutation suppresses the abnormal S-phases observed in these cells in a hUba3- and hUbc12-dependent manner. In addition, APP-BP1 has been implicated in ubiquitinylation-dependent apoptosis in neurons. Thus, APP-BP1 may be a multi-functional APP-binding protein that regulates cell cycle dynamics.

Host Species: Mouse
Clone: 20
Isotype: IgG2a
Species Reactivity [for Features Main]: Mouse
Immunogen: Human APP-BP1 aa. 348-464

Immunofluorescence, Western Blotting

Specifications

• Antigen: APP-BP1
• Concentration: 250μg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Cell Biology
• Immunogen: Human APP-BP1 aa. 348-464
• Primary or Secondary: Primary

• Clone: 20
• Applications: Western Blot
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Target Species: Canine, Human, Mouse, Rat
• Isotype: IgG2a
• Purification Method: Affinity Purified

For Research Use Only.