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ERK (pan ERK) Mouse, Unlabeled, Clone: 16, BD

Mouse Monoclonal Antibody

$281.50 - $556.00

Specifications

Antigen ERK (pan ERK)
Clone 16
Concentration 250μg/mL
Applications Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB610123
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BD Biosciences
610123
50 μg
Each for $281.50
Only null left
Add to Cart
 
BDB610124
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BD Biosciences
610124
150 μg
Each for $556.00
Only null left
Add to Cart
 
Description

Description

The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) are activated after cell stimulation by a variety of hormones and growth factors. Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation. A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton. Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation. Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers. ERK1 may be observable migrating at 44kDa and ERK2 at 42kDa in addition to a 54kDa ERK and a MAP kinase in the 90kDa range.

Host Species: Mouse
Clone: 16
Isotype: IgG2a
Species Reactivity: Mouse
Immunogen: Rat ERK2 aa. 219-358
Formula Weight [Chemical]: 42-85kDa

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Specifications

Specifications

ERK (pan ERK)
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG2a
Affinity Purified
Extracellular signal Regulated Kinases
16
Western Blot
Unconjugated
RUO
Canine, Chicken, Frog, Human, Mouse, Rat
Rat ERK2 aa. 219-358
Primary
Store undiluted at -20°C.
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