Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Mint1 Mouse, Unlabeled, Clone: 23, BD

Mouse Monoclonal Antibody

Specifications

Antigen Mint1
Isotype IgG1
Immunogen Rat Mint 1 aa. 268-377
Conjugate Unconjugated
Primary or Secondary Primary
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611028
View Documents
BD Biosciences
611028
50μg This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
BDB611029
View Documents
BD Biosciences
611029
150μg This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.
N/A
Description

Description

Neuronal communication via neurotransmitter release is mediated by the synaptic vesicle cycle. The initial step in exocytosis is the docking of the vesicle in the active zone of the plasma membrane. This step is followed by fusion of the vesicle and plasma membrane and exocytosis. Munc18-1, a major brain protein, is essential for exocytosis. It binds the vesicle fusion protein syntaxin, along with Doc2a and 2b, two proteins that associate peripherally with the synaptic vesicle. Munc18-1 is a family member of membrane trafficking proteins. Its function is thought to be mediated by two Munc18-1-interacting proteins termed Mint 1 and Mint 2, which are 50% homologous. They are expressed exclusively in brain and bind Munc18-1 (MID) with high affinity. They contain an N-terminal Munc18-1 interacting domain and C-terminal PTB (pTyr/PIP interaction) and PDZ (membrane protein interaction) domains, suggesting the ability of Mint proteins to link vesicle exocytosis to Tyr phosphorylation and/or localization at synaptic intercellular junctions. Thus, the Mint proteins, along with Munc18-1 and syntaxin, form a multimeric complex that mediates appropriate docking/fusion of synaptic vesicles.

Immunofluorescence, Western Blotting

Specifications

Specifications

Mint1
Rat Mint 1 aa. 268-377
Primary
Immunofluorescence, Western Blot
RUO
23
250μg/mL
IgG1
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal

For Research Use Only.

Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit