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  6. B7-1/CD80, Rabbit anti-Human, Clone: IDEC-114 (Galiximab), Novus Biologicals™

B7-1/CD80, Rabbit anti-Human, Clone: IDEC-114 (Galiximab), Novus Biologicals™
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Catalog No. NB016063 Shop All R&D Systems Products
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0.2 mg
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NB016063 0.025 mg
NB016064 0.2 mg
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Catalog No. NB016063 Supplier Novus Biologicals Supplier No. NBP2811000.025MG
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Description

Rabbit Monoclonal Antibody

B7-1/CD80 Monoclonal specifically detects B7-1/CD80 in Human samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Functional, Block/Neutralize.

Specifications

Antigen B7-1/CD80
Applications Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, Functional Assay, Blocking Assay
Classification Monoclonal
Clone IDEC-114 (Galiximab)
Concentration 1 mg/mL
Conjugate Unconjugated
Dilution Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, Functional, Block/Neutralize
Formulation PBS
Gene Alias Activation B7-1 antigen, B7, BB1, CD28LG1, CD28LGB7-1 antigen), CD80 antigen, CD80 molecule, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, T-lymphocyte activation antigen CD80
Gene Symbols CD80
Host Species Rabbit
Immunogen Galiximab was prepared by immunizing cynomolgus monkeys with recombinant B7-1/CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013)
Purification Method Protein A purified
Quantity 0.025 mg
Regulatory Status RUO
Research Discipline Adaptive Immunity, B Cell Development and Differentiation Markers, Cytokine Research, Immunology, Signal Transduction
Primary or Secondary Primary
Gene ID (Entrez) 941
Test Specificity Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to B7-1/CD80. B7-1/CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. B7-1/CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas.
Target Species Human
Content And Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG λ
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