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Bcl-2 Antibody (8C8), Novus Biologicals™
SDP

Catalog No. p-200045864 Shop All R&D Systems Products
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NBP229630 0.1 mg
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Catalog No. NBP229630 Supplier Novus Biologicals Supplier No. NBP229630
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Description

Mouse Monoclonal Antibody has been used in 1 publication

Bcl-2 Monoclonal specifically detects Bcl-2 in Human, Porcine, Primate, Monkey, Mouse (Negative), Rat (Negative) samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen Bcl-2
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 8C8
Concentration 0.2 mg/ml
Conjugate Unconjugated
Dilution Western Blot 0.5-3ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunohistochemistry 0.5-1ug/ml, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml
Gene Accession No. P10415
Gene Alias apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl-2
Gene Symbols BCL2
Host Species Mouse
Immunogen A synthetic peptide, aa41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein. (Uniprot: P10415 )
Molecular Weight of Antigen 25 kDa
Purification Method Protein A or G purified
Quantity 0.1 mg
Regulatory Status RUO
Research Discipline Apoptosis, Autophagy, Cancer, Cellular Markers, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 596
Test Specificity This antibody recognizes a protein of 25-26kDa, identified as the Bcl-2 lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of Bcl-2 lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2 lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express Bcl-2 protein and the small number in which the neoplastic cells are Bcl-2 negative.
Target Species Human, Pig, Primate, Mouse (Negative), Rat (Negative)
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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For Research Use Only

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