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CD25/IL-2R alpha Antibody (Basiliximab), DyLight 350 - Chimeric, Novus Biologicals™
SDP

Catalog No. NBP275902UV Shop All R&D Systems Products
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Description

Human Monoclonal Antibody

CD25/IL-2R alpha Monoclonal specifically detects CD25/IL-2R alpha in Human, Cynomolgus Monkey, Rhesus Macaque samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunofluorescence.

Specifications

Antigen CD25/IL-2R alpha
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunofluorescence
Classification Monoclonal
Clone Basiliximab
Conjugate DyLight 350
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunofluorescence
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias CD25, CD25 antigen, IDDM10, IL-2 receptor subunit alpha, IL2R, IL-2R subunit alpha, IL-2-RA, IL2-RA, interleukin 2 receptor, alpha, interleukin-2 receptor subunit alpha, p55, TAC antigen, TCGFR
Gene Symbols IL2RA
Host Species Human
Immunogen Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells.
Purification Method Protein A purified
Quantity 0.1 mL
Research Discipline Adaptive Immunity, Apoptosis, B Cell Development and Differentiation Markers, Biologically Active Proteins, Cytokine Research, Diabetes Research, Immunology, Innate Immunity, Mast Cell Markers, Signal Transduction
Primary or Secondary Primary
Gene ID (Entrez) 3559.0
Test Specificity Basiliximab recognises the human IL-2R and binds to the epitope (116)ERIYHFV(122) within the extracellular domain of the CD25 subunit -binding is abolished when 2 or more residues within the epitope are mutated. This epitope overlaps with the interaction site of CD25 and IL-2. CD25 is found in the high-affinity IL-2R ((alpha)(beta)(gamma)c) -T cells only express CD25 upon activation. IL-2 binding to IL-2R on T cells modulates proliferation and differentiation.
Target Species Human, Cynomolgus Monkey, Rhesus Macaque
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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