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DOG1/TMEM16A Antibody (DG1/447), Novus Biologicals™
SDP

Catalog No. p-5545285 Shop All R&D Systems Products
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NBP24437800 0.02 mg
NBP24437801 0.1 mg
NBP24437802 0.2 mg
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Catalog No. NBP24437800 Supplier Novus Biologicals Supplier No. NBP2443780.02MG
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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence

DOG1/TMEM16A Monoclonal specifically detects DOG1/TMEM16A in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen DOG1/TMEM16A
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone DG1/447
Concentration 0.2mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 5 - 10 ul/million cells in 0.1ml, Immunohistochemistry-Paraffin 1:100-1:200, Immunofluorescence 1:50 - 1:100
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias ANO1, anoctamin 1, DOG1, ORAOV2, TAOS2, TMEM16A
Gene Symbols TMEM16A
Host Species Mouse
Immunogen Recombinant human DOG-1 protein
Purification Method Protein A or G purified
Quantity 0.02 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55107
Test Specificity Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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