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Fc gamma RIIA/CD32a Antibody (8.7), Alexa Fluor™ 594, Novus Biologicals™
SDP

Catalog No. NP247831A94 Shop All R&D Systems Products
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NP247831A94 0.1 mL
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Catalog No. NP247831A94 Supplier Novus Biologicals Supplier No. NBP247831AF594
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Description

Mouse Monoclonal Antibody

Fc gamma RIIA/CD32a Monoclonal specifically detects Fc gamma RIIA/CD32a in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunofluorescence.

Specifications

Antigen Fc gamma RIIA/CD32a
Applications Flow Cytometry, Immunofluorescence
Classification Monoclonal
Clone 8.7
Conjugate Alexa Fluor 594
Dilution Flow Cytometry, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias CD32 antigen, CD32A, CD32MGC23887, CDw32fc-gamma-RIIa, Fc fragment of IgG, low affinity IIa, receptor (CD32), Fc fragment of IgG, low affinity IIa, receptor for (CD32), FCG2, Fc-gamma RII-a, Fc-gamma-RIIa, FcGR, FCGR2, FCGR2A1, FcRII-a, IGFR2MGC30032, IgG Fc receptor II-a, Immunoglobulin G Fc receptor II, low affinity immunoglobulin gamma Fc region receptor II-a
Gene Symbols FCGR2A
Host Species Mouse
Immunogen K562 and FcgRII+L cells
Quantity 0.1 mL
Research Discipline Immunology
Primary or Secondary Primary
Gene ID (Entrez) 2212
Test Specificity This monoclonal antibody reacts with a CD32 (FcgRII) epitope distinct from that defined by monoclonal antibody 8.26 and the epitope overlaps with that of monoclonal antibody 7.30 (cluster 4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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