Integrin beta 7, Rabbit anti-Human,Mouse, Clone: FIB27, Novus Biologicals™

Rabbit Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NB015742	Novus Biologicals NBP2810870.025MG	0.025 mg
NB015743	Novus Biologicals NBP2810870.2MG	0.2 mg

Description

Integrin beta 7 Monoclonal specifically detects Integrin beta 7 in Human, Mouse samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Block/Neutralize.

Specifications

• Antigen: Integrin beta 7
• Concentration: 1 mg/mL
• Applications: Flow Cytometry, Immunoprecipitation, Blocking Assay
• Conjugate: Unconjugated
• Host Species: Rabbit
• Research Discipline: Signal Transduction
• Formulation: PBS
• Gene ID (Entrez): 3695
• Immunogen: FIB27 was prepared by immunizing rats with TK1 cells.
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Clone: FIB27
• Dilution: Flow Cytometry, Immunoprecipitation, Block/Neutralize
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human, Mouse
• Gene Alias: Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7
• Gene Symbols: ITGB7
• Isotype: IgG κ
• Purification Method: Protein A purified
• Test Specificity: FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.