HER-2/c-erbB-2/neu Ab-5 Mouse Monoclonal Antibody, Epredia™

Provide accurate, reproducible results with the Epredia™ HER-2/c-erbB-2/neu Ab-5, Mouse Monoclonal Antibody.

Catalog Number	Mfr. No.	Concentration	Quantity
MS302P1ABX	Epredia MS302P1ABX	1mg/mL	100 μL
MS302P0	Epredia MS302P0	200μg/mL	100 μL
MS302P1	Epredia MS302P1	200μg/mL	500 μL
MS302P	Epredia MS302P	200μg/mL	1 mL
MS302PABX	Epredia MS302PABX	1mg/mL	200 μL

Description

c-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: N24

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: Intact SKBR-3 breast cancer cells

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

• Immunofluorescence
• Immunoprecipitation
• Accelerates (∽50%) HER-2 Internalization
• Inhibits (∽80%) Tumorigenic Cell Growth

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: HER-2/c-erbB-2/neu Ab-5
• Applications: Immunofluorescence, Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: EGFR Family
• Immunogen: Intact SKBR-3 breast cancer cells
• Primary or Secondary: Primary

• Clone: N24
• Classification: Monoclonal
• Form: Concentrated
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1