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Pds1 Ab-1 Mouse Monoclonal Antibody, Epredia™

Provide accurate, reproducible results with the Epredia™ Pds1 Ab-1, Mouse Monoclonal Antibody.

$434.00 - $497.00

Specifications

Antigen Pds1 Ab-1
Clone DCS-280
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Conjugate Unconjugated
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Products 7
Catalog Number Mfr. No. Formulation Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Formulation Quantity Price Quantity & Availability  
MS1511P1
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Epredia
MS1511P1
Purified Ab with BSA and Azide 500μL
Each for $497.00
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MS1511R7
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Epredia
MS1511R7
Ready-to-use for IHC (UVLP) 7mL
Each for $434.00
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MS1511P
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Epredia
MS1511P
Purified Ab with BSA and Azide 1mL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000. N/A
MS1511R1
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Epredia
MS1511R1
Ready-to-use for IHC (UVLP) 1mL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000. View substitute products »
MS1511P0
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Epredia
MS1511P0
Purified Ab with BSA and Azide 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000. N/A
MS1511P1ABX
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Epredia
MS1511P1ABX
Ab without BSA/Azide (Frozen) 100μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000. N/A
MS1511PABX
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Epredia
MS1511PABX
Ab without BSA/Azide (Frozen) 200μL This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000. N/A
Description

Description

Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways. Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together. Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle. Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry. Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase. In response to DNA damage Chk1 phosphorylates Pds1 to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase.

Host Species: Mouse

Clone: DCS-280

Isotype: IgG2a/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Human recombinant full-length Pds1 protein

Molecular Weight: 42kDa

Positive Control: HeLa cells, Tonsil

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not verified)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

Pds1 Ab-1
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RUO
Primary
IgG2a kappa
DCS-280
Monoclonal
Mouse
Cancer and Tumor Biology
Human recombinant full length Pds1 protein
SDS
Product Certifications
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