MALT1 Antibody (MT1/410), Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP229430	Novus Biologicals NBP229430	0.1 mg

Description

MALT1 Monoclonal specifically detects MALT1 in Human samples. It is validated for Western Blot, Simple Western, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: MALT1
• Concentration: 0.2 mg/ml
• Applications: Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Apoptosis, Cancer, Tumor Suppressors
• Gene Accession No.: Q9UDY8
• Gene ID (Entrez): 10892
• Immunogen: Human MALT1 recombinant fragment (aa701-808) (Uniprot: Q9UDY8)
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.

• Clone: MT1/410
• Dilution: Western Blot 0.5-1ug/ml, Simple Western 10 ug/ml, Flow Cytometry 0.5-1ug/million cells, ELISA 1-5ug/ml for coating, Immunocytochemistry/Immunofluorescence 1-2ug/ml, Immunoprecipitation 1-2ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1.0ug/ml, Immunohistochemistry-Frozen 0.5-1.0ug/ml, SDS-Page
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human
• Gene Alias: caspase-like protein, DKFZp434L132, EC 3.4.22.-, MALT associated translocation, MALT lymphoma-associated translocation, MLT1, MLTMALT-lymphoma associated translocation, mucosa associated lymphoid tissue lymphoma translocation gene 1, mucosa-associated lymphoid tissue lymphoma translocation protein 1, paracaspase
• Gene Symbols: MALT1
• Isotype: IgG1 κ
• Purification Method: Protein A or G purified
• Test Specificity: Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.

For Research Use Only