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  6. Mouse anti-Siglec-3/CD33, Clone: WM53, Azide Free, Novus Biologicals™

Mouse anti-Siglec-3/CD33, Clone: WM53, Azide Free, Novus Biologicals™
SDP

Catalog No. p-5323751 Shop All R&D Systems Products
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0.2 mg
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Catalog No. Quantity
NBP23451102 0.2 mg
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Catalog No. NBP23451102 Supplier Novus Biologicals Supplier No. NBP2345110.2 MG

Description

Mouse Monoclonal Antibody

Siglec-3/CD33 Monoclonal antibody specifically detects Siglec-3/CD33 in Human samples. It is validated for Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Frozen, Functional, CyTOF-ready.

Specifications

Antigen Siglec-3/CD33
Applications Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone WM53
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5-1ug/million cells, ELISA 1-5ug/ml for coating, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Frozen 0.5-1ug/ml, Functional, CyTOF-ready
Formulation 10mM PBS - BSA free with No Preservative
Gene Accession No. P20138
Gene Alias CD33 antigen, CD33 antigen (gp67), CD33 molecule, FLJ00391, myeloid cell surface antigen CD33, p67, sialic acid binding Ig-like lectin 3, Sialic acid-binding Ig-like lectin 3, SIGLEC-3, SIGLEC3gp67
Gene Symbols CD33
Host Species Mouse
Immunogen Human AML cells
Molecular Weight of Antigen 67 kDa
Purification Method Protein A purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Gene ID (Entrez) 945
Test Specificity Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immuno-receptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
Reconstitution Protein A purified
Target Species Human
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1 κ
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