Mouse anti-TFF1/pS2, Clone: GE2, Azide Free, Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP23462301	Novus Biologicals NBP2346230.1 MG	0.1 mg
NBP23462302	Novus Biologicals NBP2346230.2 MG	0.2 mg

Description

TFF1/pS2 Monoclonal antibody specifically detects TFF1/pS2 in Human, Primate samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, CyTOF-ready.

Specifications

• Antigen: TFF1/pS2
• Concentration: 1.0 mg/mL
• Gene Accession No.: P04155
• Formulation: 10mM PBS - BSA free with No Preservative
• Test Specificity: It recognizes a polypeptide of 6.5kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
• Primary or Secondary: Primary
• Host Species: Mouse
• Conjugate: Unconjugated
• Purification Method: Protein A purified
• Applications: Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)

• Clone: GE2 (same as R47/94)
• Immunogen: Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2.
• Gene ID (Entrez): 7031
• Reconstitution: Protein A purified
• Monoclonal or Polyclonal: Monoclonal
• Storage Requirements: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Isotype: IgG1 Kappa
• Format: Purified
• Regulatory Status: RUO

For Research Use Only