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p21/CIP1/CDKN1A Antibody (HJ21), Alexa Fluor™ 532, Novus Biologicals™
SDP

Catalog No. NP247896A32 Shop All R&D Systems Products
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NP247896A32 0.1 mL
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Catalog No. NP247896A32 Supplier Novus Biologicals Supplier No. NBP247896AF532
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Description

Mouse Monoclonal Antibody

p21/CIP1/CDKN1A Monoclonal antibody specifically detects p21/CIP1/CDKN1A in Human, Mouse, Chimpanzee, Monkey samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin).

Specifications

Antigen p21/CIP1/CDKN1A
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone HJ21
Conjugate Alexa Fluor 532
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias CAP20cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, CDKN1melanoma differentiation associated protein 6, CIP1WAF1CDK-interaction protein 1, cyclin-dependent kinase inhibitor 1A (p21, Cip1), MDA6, MDA-6, Melanoma differentiation-associated protein 6, p21, p21CIP1, p21Cip1/Waf1, PIC1, SDI1DNA synthesis inhibitor, wild-type p53-activated fragment 1
Gene Symbols CDKN1A
Host Species Mouse
Immunogen Human recombinant p21/CIP1/CDKN1A protein (Uniprot: P38936)
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 1026
Test Specificity This monoclonal antibody recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. It is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdks and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
Target Species Human, Mouse, Chimpanzee, Monkey
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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