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  6. P2X7/P2RX7 Antibody (Hano43) - BSA Free, Novus Biologicals™

P2X7/P2RX7 Antibody (Hano43) - BSA Free, Novus Biologicals™
SDP

Catalog No. NB018511 Shop All R&D Systems Products
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0.025 mg
0.1 mg
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NB018511 0.025 mg
NBP14089401 0.1 mg
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Catalog No. NB018511 Supplier Novus Biologicals Supplier No. NBP1408940.025MG
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Description

Rat Monoclonal Antibody has been used in 2 publications

P2X7/P2RX7 Monoclonal specifically detects P2X7/P2RX7 in Mouse samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.

Specifications

Antigen P2X7/P2RX7
Applications Immunocytochemistry, Flow Cytometry, Immunofluorescence
Classification Monoclonal
Clone Hano43
Concentration 1 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 1:25-1:200, Immunocytochemistry/Immunofluorescence 1:10-1:2000
Formulation PBS (pH 7.4) with 0.09% Sodium Azide
Gene Accession No. Q9Z1M0
Gene Alias ATP receptor, MGC20089, P2X purinoceptor 7, P2X7P2X7 receptor, P2X7R, P2Z receptor, Purinergic receptor, purinergic receptor P2X, ligand-gated ion channel, 7, purinergic receptor P2X7 variant A
Gene Symbols P2RX7
Host Species Rat
Immunogen A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.
Purification Method Protein G purified
Quantity 0.025 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5027
Test Specificity This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Target Species Mouse
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG2b
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For Research Use Only

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