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Tocris Bioscience™ PHT 427

Dual Akt and PDK1 inhibitor; antitumor

Specifications

Purity	>98%
Product Type	PHT 427
Molecular Weight (g/mol)	409.61
Inhibitors	PHT 427

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Products 2

Catalog Number	Mfr. No.	Quantity	Price	Quantity & Availability
Catalog Number	Mfr. No.	Quantity	Price	Quantity & Availability
45-981-0 View Documents View Product Certificates	Tocris Bioscience™ 4598/10	10 mg	N/A		N/A	N/A

45-985-0 View Documents View Product Certificates	Tocris Bioscience™ 4598/50	50 mg	N/A		N/A	N/A

Description

Dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

Specifications

Purity	>98%
Product Type	PHT 427
Molecular Weight (g/mol)	409.61
Inhibitors	PHT 427

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Tocris Bioscience™ PHT 427

Specifications

Description

Specifications

Documents