Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ SANT-1

Tocris Bioscience™ SANT-1
GREENER_CHOICE

Catalog No. 197450
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Has been used in protocols to generate pancreatic β cells from hPSCs.

For more information about how SANT-1 may be used, see our protocol:

Generation of β cells from hPSCs

Chemical Identifiers

CAS 304909-07-7
Molecular Formula C23H27N5

Specifications

Quantity 50 mg
Formula Weight 373.5
Purity >99%
Molecular Weight (g/mol) 373.50
Chemical Name or Material SANT-1

Safety and Handling

Recommended Storage Desiccate at +4°C
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.