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Tropomyosin-1, Rat anti-Mouse, Human, Clone: 7F8B8, Millipore Sigma™

Rat Monoclonal Antibody

$192.34 - $482.80

Specifications

Antigen Tropomyosin-1
Clone 7F8B8
Dilution Immunocytochemistry Analysis: A representative lot detected Tropomyosin-1 in Immunocytochemistry applications (Brayford, S., et. al. (2016). Curr Biol. 26(10):1312-8).
Applications Immunocytochemistry, Western Blot
Classification Monoclonal
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MABT136525
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MilliporeSigma
MABT136525UL
25 μL
Each for $192.34
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MABT1365100
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MilliporeSigma
MABT1365100UL
100 μL
Each for $482.80
Only null left
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Description

Description

Anti-Tropomyosin-1, clone 7F8B8, Cat. No. MABT1365, is a rat monoclonal antibody that detects Tropomyosin-1 and has been tested for use in Immunocytochemistry and Western Blotting.

Tropomyosin alpha-1 chain (UniProt: P09493; also known as Alpha-tropomyosin, Tropomyosin-1) is encoded by the TPM1 (also known as C15orf13, TMSA) gene (Gene ID: 7168) in human. Tropomyosin-1 is a cytoskeletal protein that associates with F-actin stress fibers. It binds to actin filaments in muscle and non-muscle cells and plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. It stabilizes actin filaments and regulates the interaction of actin filament with other actin-binding proteins. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Tropomyosin-1 is a homodimeric protein, but can form heterodimer of an alpha (TPM1, TPM3, or TPM4) and a beta (TPM2) chain. Mutations in TPM1 gene have been linked to cardiomyopathy characterized by ventricular hypertrophy and ventricular dilation and impaired systolic function that results in congestive heart failure and arrhythmia. Ten different isoforms of Tropomyosin-1 have been described that are produced by alternative splicing.
Specifications

Specifications

Tropomyosin-1
Immunocytochemistry Analysis: A representative lot detected Tropomyosin-1 in Immunocytochemistry applications (Brayford, S., et. al. (2016). Curr Biol. 26(10):1312-8).
Monoclonal
Purified
RUO
Mouse, Human
Tropomyosin alpha-1 chain;Alpha-tropomyosin;Tropomyosin-1
TPM1;C15orf13;TMSA
IgG2a κ
Protein G purified
Clone 7F8B8 detects human and murine Tropomyosin-1. It targets an epitope with in the N-terminal region.
7F8B8
Immunocytochemistry, Western Blot
Unconjugated
Rat
Cell Structure
Purified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
NP_000357.3
KLH-conjugated linear peptides corresponding to 24 amino acids from the N-terminal region of isoform 5 and 4 amino acids from the N-terminal region of isoform 2 of human tropomyosin-1.
Primary
Stable for 1 year at 2-8°C from date of receipt.
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