TYRP1 Mouse anti-Human, Mouse, Clone-TYRP1/807, Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NB254306100	Novus Biologicals NBP254306100UG	100 μg
NB254306200	Novus Biologicals NBP254306200UG	200 μg

Description

TYRP1 Monoclonal specifically detects TYRP1 in Human, Mouse samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: TYRP1
• Concentration: 1 mg/mL
• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), CyTOF
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Formulation: PBS with No Preservative
• Gene ID (Entrez): 7306
• Immunogen: Recombinant full-length human TYRP1 protein
• Primary or Secondary: Primary
• Content And Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
• Molecular Weight of Antigen: 75 kDa

• Clone: TYRP1/807
• Dilution: Flow Cytometry 0.5 - 1 ug/million cells, Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml, Immunohistochemistry-Paraffin 3 - 6 ug/ml, CyTOF-ready
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human, Mouse
• Gene Alias: b-PROTEIN, CAS25,6-dihydroxyindole-2-carboxylic acid oxidase, Catalase B, CATB, EC 1.14.18, EC 1.14.18.-, EC 1.14.18.1, Glycoprotein 75, GP75DHICA oxidase, Melanoma antigen gp75, TRP-1, TRPTYRP, tyrosinase-related protein 1TRP1, TYRRP
• Gene Symbols: TYRP1
• Isotype: IgG2a κ
• Purification Method: Protein A or G purified
• Test Specificity: It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.