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Filtered Search Results
Medchemexpress LLC Ac-lys-val-cit-pabc-mmae | 1650569-89-3
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Ac-Lys-Val-Cit-PABC-MMAE is a agent-linker conjugate for ADC Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162)[1]
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Medchemexpress LLC Val-Cit-amide-Cbz-N(Me)-Maytansine | 1628543-59-8 | 97.9% | 1140.71 g/mol | C55H78ClN9O15 | 25 MG
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Val-Cit-amide-Cbz-N(Me)-Maytansine is a maytansine-based payload intermediate intended for research use in antibody-drug conjugate (ADC) synthesis and bioconjugation. It contains a valine-citrulline (Val-Cit) cleavable dipeptide linker and a Cbz-protected N-methyl maytansine moiety, provided as a powder for laboratory conjugation workflows.
- Val-Cit cleavable dipeptide linker for cathepsin B-mediated release.
- Cbz-protected N-methyl maytansine payload compatible with common conjugation chemistries.
- High purity suitable for research applications.
- Powder form with defined storage conditions for long-term stability.
- Suitable as an intermediate for ADC construction and payload development.
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Cayman Chemical Cyclo L-Pro-L-Val 25mg
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A diketopiperazine; active against S. aureus and B. subtilis (MICs = 16.3 and 18.2 UG/ml, respectively); modulates LuxR-dependent quorum sensing systems but not lacZ-based reporter fusions; inhibits activation of a LuxR-dependent E. coli biosensor by 3-oxo-hexanoyl-homoserine lactone (IC50 = 0.4 mM) and activates violacein pigment production in the LuxR-dependent C. violaceum acyl homoserine lactone reporter strain CV026
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Medchemexpress LLC Py-MAA-Val-Cit-PAB-MMAE | 2247398-68-9 | 98.5% | 1446.79 | C72H111N13O16S | 5 MG
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Py-MAA-Val-Cit-PAB-MMAE is a drug-linker conjugate consisting of monomethyl auristatin E (MMAE) attached via a Py-MAA-Val-Cit-PAB cleavable peptide linker and intended for use in antibody-drug conjugate research and synthesis, including preparation of TRAILR2-targeting constructs.
- Used as a building block for ADC synthesis.
- Contains a Val-Cit-PAB cleavable peptide linker.
- Includes monomethyl auristatin E payload for cytotoxic activity.
- High purity suitable for preclinical research.
- Available in small milligram quantities for synthesis workflows.
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Medchemexpress LLC Mal-di-EG-Val-Cit-PAB-MMAF | 96.0% | 1447.71 | C72H110N12O19 | 50 MG
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MAL-di-EG-Val-Cit-PAB-MMAF is a drug-linker conjugate used in antibody-drug conjugate research that couples a cleavable valine-citrulline p-aminobenzyl linker to monomethyl auristatin F (MMAF).
- Drug-linker conjugate with MMAF payload.
- Molecular formula: C72H110N12O19.
- Molecular weight: 1447.71.
- Purity: 95.99% initial; select batches up to 98.56%.
- Appearance: white to off-white solid.
- Storage: 4°C under nitrogen; unstable in solution, prepare fresh solutions.
- Available sizes: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg; larger sizes by quote.
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OCC1c2ccccc2-c2ccccc12)C(O)=O | 25g | 205398243](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000483030.jpg-250.jpg)
eMolecules 68858-20-8 | Fmoc-Val-OH | Combi-Blocks | MFCD00037124 | 339.391 | C20H21NO4 | 97.000 | CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O | 25g | 205398243
Fmoc-Val-OH | Combi-Blocks | 68858-20-8 | MFCD00037124 | 339.391 | C20H21NO4 | 97.000 | CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O | 25g | 205398243
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Bachem H-Val-AMC
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H-Val-AMC Trifluoroacetate, 191723-67-8, C15H18N2O3, Mr 274.32, 250mg. H-Val-AMC trifluoroacetate salt.
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STA PHARMACEUTICAL US LLC Fmoc-N-Me-D-Nva-OH | 10 g | CAS 1799443-42-7 | MDL MFCD07366866
Fmoc-N-Me-D-Nva-OH is a Amino Acid reagent (Subcategory: N-Me AA) sold by WuXi TIDES. Offered in 10 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 1799443-42-7
- MDL: MFCD07366866
- InChIKey: HKELUUGCKFRJQM-LJQANCHMSA-N
- Molecular Weight: 353.418
- Molecular Formula: C21H23NO4
- Purity: ≥95%
- Container Type: 60 mL HDPE
- Pack Size: 10 g
- Net Weight: 10 g
- Gross Weight: 25 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)pentanoic acid
- SMILES: CCC[C@@H](N(C(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)C)C(O)=O
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eMolecules 54895-12-4 | Boc-DL-Val-OH | Combi-Blocks | MFCD00069973 | 217.265 | C10H19NO4 | 98.000 | CC(C)C(NC(=O)OC(C)(C)C)C(O)=O | 25g | 249363798
Boc-DL-Val-OH | Combi-Blocks | 54895-12-4 | MFCD00069973 | 217.265 | C10H19NO4 | 98.000 | CC(C)C(NC(=O)OC(C)(C)C)C(O)=O | 25g | 249363798
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OCC1c2ccccc2-c2ccccc12)C(O)=O | 5g | 552644816](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000471781.jpg-250.jpg)
eMolecules 68858-20-8 | Fmoc-Val-OH | Ambeed | MFCD00037124 | 339.391 | C20H21NO4 | 97.000 | CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O | 5g | 552644816
Fmoc-Val-OH | Ambeed | 68858-20-8 | MFCD00037124 | 339.391 | C20H21NO4 | 97.000 | CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O | 5g | 552644816
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eMolecules 516-06-3 | H-DL-Val-OH | Ambeed | MFCD00004267 | 117.148 | C5H11NO2 | 98.000 | CC(C)C(N)C(O)=O | 100g | 572824623
H-DL-Val-OH | Ambeed | 516-06-3 | MFCD00004267 | 117.148 | C5H11NO2 | 98.000 | CC(C)C(N)C(O)=O | 100g | 572824623
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eMolecules 68858-20-8 | N-Fmoc-L-valine | Accela ChemBio (ASD) | MFCD00037124 | 339.391 | C20H21NO4 | 98.000 | CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O | 100g | 455888881
N-Fmoc-L-valine | Accela ChemBio (ASD) | 68858-20-8 | MFCD00037124 | 339.391 | C20H21NO4 | 98.000 | CC(C)[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O | 100g | 455888881
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eMolecules 516-06-3 | DL-valine | Combi-Blocks | MFCD00004267 | 117.148 | C5H11NO2 | 98.000 | CC(C)C(N)C(O)=O | 100g | 290697361
DL-valine | Combi-Blocks | 516-06-3 | MFCD00004267 | 117.148 | C5H11NO2 | 98.000 | CC(C)C(N)C(O)=O | 100g | 290697361
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Cambridge Isotope Laboratories L-VALINE-N-T-BOC (15N, 98%), 0.5 G
L-VALINE-N-T-BOC (15N, 98%), 0.5 G
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Medchemexpress LLC Dianhydrodulcitol | 23261-20-3 | 98.0% | 146.14 | 5 MG
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VAL-083 is an alkylating agent that creates N7 methylation on DNA, exhibiting antitumor activity. It suppresses cell growth and induces apoptosis in U251 and SF188 cells, and inhibits T98G cell growth in a dose-dependent manner. VAL-083 also inhibits the proliferation, migration, and invasion of HUVEC and U251 cells, reducing the expression of MMP2, VEGF, VEGFR2, and FGF2.
- Induces cell cycle arrest at the G2/M phase in glioma cell lines.
- Enhances radiosensitivity by activating the p53-p21 and CDC25C-CDK1 cascades.
- Inhibits angiogenesis in zebrafish.
- Significantly blocks the growth of LN229 cells in mice.
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