Lipopolysaccharides, from E. coli O128:B12, are endotoxins and TLR4 activators. These S (smooth) type LPS possess a typical three-part structure: O-antigen, R3-type core oligosaccharide, and lipid A. They activate TLR-4 in immune cells and can be used to construct animal models of neonatal brain inflammation, potentially influencing preterm birth in neonates.
- Activates TLR-4 in immune cells
- Used to construct animal models of neonatal brain inflammation
- May influence preterm birth in neonates
- Classified as S (smooth) type LPS
- Possesses O-antigen, R3-type core oligosaccharide, and lipid A structure