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Various organic compounds consisting of carbon, hydrogen, and oxygen atoms that are found in foods and living tissues; typically broken down to release energy; includes sugars, sugar alcohols, sugar acids and derivatives, glycosyl compounds, and more.
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-Pompilidotoxin ( -PMTX CAS 216064-36-7) is a peptide neurotoxin isolated from the venom of the solitary wasp Batozonellus maculifrons Composed of 13 amino acids (C71H124N22O17) -PMTX modulates neuronal excitability by selectively slowing the inactivation of voltage-gated sodium (Na ) channels without affecting cardiac Na channels This action is thought to involve interaction with neurotoxin receptor site 3 on the extracellular surface of neuronal Na channels Compared to -pompilidotoxin -PMTX exhibits greater potency in enhancing synaptic transmission at neuromuscular junctions -PMTX serves as a valuable tool for investigating Na channel kinetics and the molecular mechanisms regulating synaptic transmission
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Eriodictyol-7-O-glucoside is a flavonoid and Nrf2 activator, demonstrating significant scavenging effects on hydroxyl radicals and superoxide anions. It increases Nrf2 nuclear localization and induces Nrf2/ARE-dependent gene expression, providing protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. It also shows neuroprotective efficacy in a rat model of focal cerebral ischemia.
Nrf2 activator
Scavenges hydroxyl radicals and superoxide anions
Increases nuclear localization of Nrf2
Induces Nrf2/ARE-dependent gene expression
Protects against oxidative insult
Demonstrates neuroprotective efficacy in focal cerebral ischemia models
Can be used for the study of stroke
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