Lipids and Lipid Derivatives
Medchemexpress LLC L-Proline, N-acetyl-L-seryl-L-α-aspartyl-L-lysyl- (acetate) | 99.1% | 25 MG
Goralatide, a natural tetrapeptide, is a physiological regulator of hematopoiesis and can inhibit primitive haematopoietic cell proliferation.
- Purity of 99.1%
- Molecular weight of 547.56
- Molecular formula C22H37N5O11
- Appears as a white to off-white solid
- Sequence shortening: Ac-SDKP
- Solubility in DMSO: 100 mg/mL (182.63 mM)
- Physiological regulator of hematopoiesis
- Inhibits primitive haematopoietic cell proliferation
Medchemexpress LLC L-Proline, L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-, acetate | 2828433-33-4 | 99.4% | 873.97 | 100 MG
Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide that forms stable complexes with Cu2+. It is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) (4-10) and exhibits immunomodulatory, nootropic, and neuroprotective activities. It is used in research for central nervous system diseases such as Alzheimer's disease and cerebral ischemia.
- Reduces Aβ oligomer levels.
- Increases survival and stimulates choline acetyltransferase activity in cholinergic neurons.
- Increases BDNF and NGF levels in glial cells.
- Ameliorates effects in a rat model of focal cerebral ischemia.
- Increases 5-HIAA concentration in hypothalamus and striatum of mice.
- Affects gene expression related to immune and vascular systems in ischemia rats.
Medchemexpress LLC N-Propargylglycine | 58160-95-5 | 99.7% | C5H7NO2 | 10MM/1ML
N-Propargylglycine is a brain-penetrant, orally active PRODH inhibitor. It irreversibly inhibits proline and 4-hydroxyproline catabolism by covalently modifying enzyme-bound FAD and active site lysine. This compound induces UPRmt, upregulates mitochondrial chaperones, and enhances mitochondrial proteostasis. It also stimulates neural processes, increases brain proline levels, and normalizes Huntington's disease transcriptomes. Additionally, N-Propargylglycine reduces hyperoxaluria and prevents calcium oxalate stone formation.
- Brain-penetrant and orally active PRODH inhibitor
- Irreversible inhibition of proline catabolism
- Enhances mitochondrial proteostasis
- Stimulates neural processes; increases brain proline
- Normalizes Huntington's disease transcriptomes
- Reduces hyperoxaluria; prevents calcium oxalate stones
- Research applications include breast cancer and neurodegenerative disorders
Medchemexpress LLC N-Propargylglycine | 58160-95-5 | 99.7% | C5H7NO2 | 25 MG
N-Propargylglycine is a brain-penetrant, orally active PRODH inhibitor. It works by covalently modifying enzyme-bound FAD and active site lysine, leading to enzyme structural distortion, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. It can induce UPRmt, upregulate mitochondrial chaperones, and enhance mitochondrial proteostasis.
- Brain-penetrant and orally active.
- Irreversibly inhibits proline oxidation.
- Induces mitochondrial unfolded protein response.
- Blocks astrocytic L-proline consumption.
- Stimulates neural processes and increases brain amino acid levels.
- Reduces hyperoxaluria and prevents calcium oxalate stone formation.
- Used in research for breast cancer, neurodegenerative disorders, and primary hyperoxaluria.
Medchemexpress LLC N-Propargylglycine | 58160-95-5 | 99.70% | C5H7NO2 | 100 MG
N-Propargylglycine is a brain-penetrant and orally active PRODH inhibitor. It functions by inhibiting proline and 4-hydroxyproline catabolism, enhancing mitochondrial proteostasis, and stimulating neural processes. This compound is used in research for various neurodegenerative disorders, breast cancer, and primary hyperoxaluria type 2.
- Brain-penetrant and orally active PRODH inhibitor
- Inhibits proline and 4-hydroxyproline catabolism
- Enhances mitochondrial proteostasis
- Stimulates neural processes
- Useful in research for neurodegenerative disorders and breast cancer
- Reduces hyperoxaluria and prevents calcium oxalate stone formation
Medchemexpress LLC N-propargylglycine | 58160-95-5 | 99.7% | C5H7NO2 | 10MG
N-propargylglycine is an orally active, irreversible inhibitor of proline dehydrogenase (PRODH) used in biochemical and pharmacological research. It exhibits reported antitumor activity and is applied in studies of mitochondrial metabolism and neurodegenerative disease mechanisms. Available as a solid and as a 10 mM solution in DMSO, it has formula C5H7NO2 and reported purity 99.7%.
- Irreversible inhibitor of proline dehydrogenase (PRODH).
- Orally active small molecule suitable for in vivo and in vitro studies.
- Reported antitumor activity supports oncology research.
- Useful for studies of mitochondrial metabolism and neurodegenerative disease mechanisms.
- Offered in solid form and as a 10 mM solution in DMSO for convenience.
Medchemexpress LLC N-propargylglycine | 58160-95-5 | MFCD11168312 | 99.7% | 113.11 | C5H7NO2 | 5 MG
N-propargylglycine is an orally active, irreversible inhibitor of proline dehydrogenase (PRODH) used in research on mitochondrial metabolism and neurodegenerative diseases. It has reported antitumor activity and is supplied as an off-white to light-yellow solid for laboratory research.
- Orally active, irreversible PRODH inhibitor.
- Applicable to studies of mitochondrial metabolism and neurodegeneration.
- Reported antitumor activity supports cancer research use.
- High purity (99.7%) for reproducible experimental results.
- Solid form facilitates storage and handling in the laboratory.
- Available in small package sizes suitable for screening and pilot studies.