Nucleosides and Analogues
Medchemexpress LLC Adenosine 5'-triphosphate | 56-65-5 | 99.9% | 5 G
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. It provides metabolic energy for pumps and acts as a coenzyme in cells. ATP is also an important endogenous signaling molecule in immunity and inflammation, capable of activating the NLRP3 inflammasome and inducing IL-1β and chemokine secretion. It exhibits anti-bacterial infection effects and can protect mice against bacterial infection.
- Provides metabolic energy and acts as a coenzyme
- Functions as an important endogenous signaling molecule in immunity and inflammation
- Activates the NLRP3 inflammasome
- Induces IL-1β and chemokine secretion
- Exhibits anti-bacterial infection effects
- Protects against bacterial infection in mice
- Synergistically activates the NLRP3 inflammasome with LPS in HGFs
- Induces secretion of IL-1β, KC, and MIP-2 from BMDMs
- Promotes neutrophil chemotaxis
Medchemexpress LLC NBI-961 (formerly CMP3a) | 2225902-98-5 | 99.7% | 568.61 g/mol | C28H27F3N6O2S | 10 MG
NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation and induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells. It is supplied as a solid, light yellow to yellow research-use-only compound and is available in small amounts for laboratory studies.
- High purity (99.7%).
- Molecular weight 568.61 g/mol.
- Chemical formula C28H27F3N6O2S.
- Soluble in DMSO at 100 mg/mL (requires ultrasonic).
- Powder storage: -20°C for 3 years; 4°C for 2 years.
- Intended for laboratory research use only; not for human or animal use.
Medchemexpress LLC Adenosine 5'-diphosphate (disodium) | 16178-48-6 | 99.9% | 1 MG
Adenosine 5'-diphosphate disodium is a nucleoside diphosphate, resulting from ATP dephosphorylation by ATPases. This compound functions as a crucial platelet aggregation agent, playing a significant role in hemostasis and the processes involved in the development and extension of arterial thrombosis.
- Platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis.
- Induces human platelets aggregation and [Ca2+]i increasing in platelets, B10 cells, and P2Y1-transfected cells (at 10 μmol/L).
- Increases cAMP levels in human platelets and in B10 cells (at 5 μmol/L).
Medchemexpress LLC Adenosine receptor inhibitor 2 | 2550401-76-6 | 99.1% | 406.28 g/mol | C17H20BrN5O2 | 10 MG
Adenosine receptor inhibitor 2 is a small-molecule research compound that acts as an adenosine receptor inhibitor with reported dual affinity for A1 and A2A receptors. It is supplied as a high-purity analytical standard intended for pharmacology and receptor-binding studies.
- High-purity small-molecule suitable for receptor pharmacology.
- Dual affinity for A1 and A2A adenosine receptors.
- Chemical formula C17H20BrN5O2, molecular weight 406.28 g/mol.
- CAS number 2550401-76-6 for substance identification.
- Available in milligram-scale packages, including 10 mg.
- Structural identifiers available (SMILES) for cheminformatics use.
- For research use only; not for human consumption or clinical use.
Medchemexpress LLC Ribavirin | 36791-04-5 | 99.96% | 200 MG
Ribavirin (ICN-1229) is an antiviral agent effective against a wide range of viruses. It exhibits activity against Hepatitis C Virus (HCV), Human Immunodeficiency Virus type 1 (HIVl), and Respiratory Syncytial Virus (RSV). Additionally, Ribavirin demonstrates anti-orthopoxvirus and anti-variola activities.
- Broad-spectrum antiviral agent targeting various viruses including HCV, HIVl, and RSV.
- Effective against orthopoxviruses and variola.
Sigma Aldrich Fine Chemicals Biosciences alpha-Nicotinamide adenine dinucleotide from Saccharomyces cerevisiae, <=1% beta-isomer, >=95% | 7298-93-3 | MFCD00134828 | 10MG
alpha-Nicotinamide adenine dinucleotide from Saccharomyces cerevisiae, <=1% beta-isomer, >=95% | Purity: >=95% | Mol Wt: 663.43 | 7298-93-3 | MFCD00134828 | 10MG
TARGETMOL CHEMICALS INC 5-FLUORO-2-DEOXYCYTIDINE 50MG
Also available in 2 mg 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) . purity: 99%
Medchemexpress LLC Nicotinamide (Niacinamide) | 98-92-0 | 99.99% | 100 MG
Nicotinamide is a form of vitamin B3 (niacin) that inhibits SIRT2 and SIRT1 activity. It increases cellular NAD+, ATP, and ROS levels, and is known to inhibit tumor growth, improve survival, and exhibit anti-HBV activity. It is intended for research use only.
- Inhibits SIRT2 and SIRT1 activity
- Increases cellular NAD+, ATP, and ROS levels
- Inhibits tumor growth and improves survival
- Possesses anti-HBV activity
- Reduces cell number in A375 and SK-MEL-28 cells
- Promotes pancreatic cell differentiation from human embryonic stem cells
Medchemexpress LLC Lamivudine | 134678-17-4 | 99.9% | 500 MG
Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). It is capable of inhibiting both HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus. Additionally, lamivudine salicylate has the ability to penetrate the central nervous system (CNS).
- Orally active nucleoside reverse transcriptase inhibitor (NRTI)
- Inhibits HIV reverse transcriptase 1/2
- Inhibits reverse transcriptase of hepatitis B virus
- Salicylate form can penetrate the CNS
Medchemexpress LLC Adenosine (standard) | 58-61-7 | >99.4% | 100 MG
Adenosine (Standard) is the analytical standard of Adenosine, intended for research and analytical applications. Adenosine (Adenine riboside) is a ubiquitous endogenous autacoid that influences nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
- Analytical standard for research and analytical applications
- Acts through G protein-coupled receptors A1, A2A, A2B, and A3
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS
Medchemexpress LLC Riboflavin 5'-(trihydrogen diphosphate), P'→5'-ester with adenosine | 146-14-5 | 98.9% | 5 MG
Flavin adenine dinucleotide (FAD) is a redox cofactor and prosthetic group of a protein, involved in several important enzymatic reactions in metabolism. It targets endogenous metabolites and functions within the metabolic enzyme/protease pathway. It is soluble in H2O at ≥ 100 mg/mL (127.30 mM). It should be stored at 4°C, protected from light. In solvent, it can be stored at -80°C for 6 months or -20°C for 1 month, also protected from light.
Apexbio Technology LLC 8-Azido-ATP(Synonyms: 8-Azidoadenosine 5'-triphosphate, 8-N3-ATP, 8-Azido-ATP, 8-Azidoadenosine triphosphate), 10ul (100 mM).
8-Azido-ATP is a ribonucleoside triphosphate analog with an azido group substitution at the adenine C-8 position It acts primarily as an ATP mimic interacting with poly(A) polymerase (PAP) specifically illustrated using yeast poly(A) polymerase (yPAP) Incorporation of 8-azido-ATP into growing polyadenylation chains results in premature termination and moderately shorter poly(A) tails relative to natural ATP substrates Due to its chain-terminating capacity and altered substrate specificity 8-azido-ATP is applied in biochemical studies examining enzyme fidelity nucleotide selection mechanisms and RNA polymerase activity
Medchemexpress LLC Uridine 3',5'-diphosphate | 2922-95-4 | 99.7% | 404.16 g/mol | C9H14N2O12P2 | 10 MG
Uridine 3',5'-diphosphate is a nucleotide derivative used as a competitive RNase inhibitor in biochemical research. It is supplied as a powdered reagent for laboratory use and is intended for research purposes only. Key chemical identifiers include CAS 2922-95-4, molecular formula C9H14N2O12P2, and molecular weight 404.16 g/mol.
- High purity (99.65%).
- Powder form suitable for long-term storage.
- Stable at -20°C for extended storage; in solvent stability guidelines available.
- Functionally used as a competitive RNase inhibitor in biochemical assays.
- Well-characterized molecular identity for reproducible research results.
- Intended for research use only; not for clinical or human use.
eMolecules 1094-61-7 | ?-Nicotinamide mononucleotide | AA Blocks LLC | MFCD00038748 | 334.221 | C11H15N2O8P | 0.000 | NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O | 5g | 435952318
?-Nicotinamide mononucleotide | AA Blocks LLC | 1094-61-7 | MFCD00038748 | 334.221 | C11H15N2O8P | 0.000 | NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O | 5g | 435952318